Evolution of contrast agents for ultrasound imaging and ultrasound-mediated drug delivery

V Paefgen, D Doleschel, F Kiessling - Frontiers in pharmacology, 2015 - frontiersin.org
Ultrasound (US) is one of the most frequently used diagnostic methods. It is a non-invasive,
comparably inexpensive imaging method with a broad spectrum of applications, which can …

Nanoscale theranostics for physical stimulus-responsive cancer therapies

Q Chen, H Ke, Z Dai, Z Liu - Biomaterials, 2015 - Elsevier
Physical stimulus-responsive therapies often employing multifunctional theranostic agents
responsive to external physical stimuli such as light, magnetic field, ultra-sound …

Ultrasound contrast agents: a review

BB Goldberg, JB Liu, F Forsberg - Ultrasound in medicine & biology, 1994 - Elsevier
During the past 25 years, many attempts have been made to establish effective ultrasound
contrast agents for both cardiac and noncardiac applications. The ideal ultrasound contrast …

The fabrication of novel nanobubble ultrasound contrast agent for potential tumor imaging

Z **ng, J Wang, H Ke, B Zhao, X Yue, Z Dai… - Nanotechnology, 2010 - iopscience.iop.org
Novel biocompatible nanobubbles were fabricated by ultrasonication of a mixture of Span
60 and polyoxyethylene 40 stearate (PEG40S) followed by differential centrifugation to …

Ultrasound targeted microbubble destruction for drug and gene delivery

CR Mayer, NA Geis, HA Katus… - Expert opinion on drug …, 2008 - Taylor & Francis
Background: Gas-filled microbubbles have been used as ultrasound contrast agents for
some decades. More recently, such microbubbles have evolved as experimental tools for …

Advances in molecular imaging with ultrasound

R Gessner, PA Dayton - Molecular imaging, 2010 - journals.sagepub.com
Ultrasound imaging has long demonstrated utility in the study and measurement of anatomic
features and noninvasive observation of blood flow. Within the last decade, advances in …

Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient

J Lanphere, EJS Pierre, G Kapoglis… - US Patent …, 2010 - Google Patents
(57) ABSTRACT A composition includes a plurality of particles. At least some of the plurality
of particles include cross-linked polyvinyl alcohol and have a diameter of about 500 microns …

Ultrasound contrast: gas microbubbles in the vasculature

AL Klibanov - Investigative Radiology, 2021 - journals.lww.com
Gas-filled microbubbles are currently in clinical use as blood pool contrast agents for
ultrasound imaging. The goal of this review is to discuss the trends and issues related to …

Gas-filled polymeric microbubbles for ultrasound imaging

S Cohen, AK Andrianov, M Wheatley… - US Patent …, 1996 - Google Patents
Compositions, methods for preparing and methods of using ajr~? lled polymeric
microcapsules for ultrasound imaging are disclosed. Air-encapsulating microcapsules are …

Embolic compositions

B Bell, IITV Casey, WJ Shaw - US Patent 7,588,825, 2009 - Google Patents
Embolic compositions and methods of delivering the compo sitions are disclosed. In some
embodiments, an embolic com position includes a first collection of particles having a first …