The selenoprotein glutathione peroxidase 4: from molecular mechanisms to novel therapeutic opportunities
K Weaver, R Skouta - Biomedicines, 2022 - mdpi.com
The selenoprotein glutathione peroxidase 4 (GPX4) is one of the main antioxidant mediators
in the human body. Its central function involves the reduction of complex hydroperoxides into …
in the human body. Its central function involves the reduction of complex hydroperoxides into …
Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential
X Ding, L Gao, Z Han, S Eleuteri, W Shi, Y Shen… - Ageing research …, 2023 - Elsevier
Parkinson's Disease (PD) is characterized by the progressive loss of dopaminergic neurons
in the substantia nigra (SN), leading to motor and non-motor symptoms. While the exact …
in the substantia nigra (SN), leading to motor and non-motor symptoms. While the exact …
[HTML][HTML] Metabolic changes induced by heavy metal copper exposure in human ovarian granulosa cells
J Lin, L Wang, M Huang, G Xu, M Yang - Ecotoxicology and Environmental …, 2024 - Elsevier
Copper (Cu) is a common heavy metal and a hazardous environmental pollutant. Emerging
epidemiological evidence suggests that Cu exposure is associated with female infertility …
epidemiological evidence suggests that Cu exposure is associated with female infertility …
Glutathione in protein redox modulation through S-glutathionylation and S-nitrosylation
S-glutathionylation and S-nitrosylation are reversible post-translational modifications on the
cysteine thiol groups of proteins, which occur in cells under physiological conditions and …
cysteine thiol groups of proteins, which occur in cells under physiological conditions and …
Consequences of disturbing manganese homeostasis
Manganese (Mn) is an essential trace element with unique functions in the body; it acts as a
cofactor for many enzymes involved in energy metabolism, the endogenous antioxidant …
cofactor for many enzymes involved in energy metabolism, the endogenous antioxidant …
Krebs cycle: activators, inhibitors and their roles in the modulation of carcinogenesis
A fundamental metabolic feature of cancerous tissues is high glucose consumption. The rate
of glucose consumption in a cancer cell can be 10–15 times higher than in normal cells …
of glucose consumption in a cancer cell can be 10–15 times higher than in normal cells …
Iron metabolism and ferroptosis in epilepsy
S Chen, Y Chen, Y Zhang, X Kuang, Y Liu… - Frontiers in …, 2020 - frontiersin.org
Epilepsy is a disease characterized by recurrent, episodic, and transient central nervous
system (CNS) dysfunction resulting from an excessive synchronous discharge of brain …
system (CNS) dysfunction resulting from an excessive synchronous discharge of brain …
Susceptibility of the patients infected with Sars-Cov2 to oxidative stress and possible interplay with severity of the disease
AC Gadotti, AL Lipinski, FTF Vasconcellos… - Free Radical Biology …, 2021 - Elsevier
Several recent reviews have suggested a role of oxidative stress in the pathophysiology of
COVID-19, but its interplay with disease severity has not been revealed yet. In the present …
COVID-19, but its interplay with disease severity has not been revealed yet. In the present …
Oxidative stress as a common key event in developmental neurotoxicity
Y Nishimura, Y Kanda, H Sone… - Oxidative medicine and …, 2021 - Wiley Online Library
The develo** brain is extremely sensitive to many chemicals. Perinatal exposure to
neurotoxicants has been implicated in several neurodevelopmental disorders, including …
neurotoxicants has been implicated in several neurodevelopmental disorders, including …
The impact of glutathione metabolism in autism spectrum disorder
This paper reviews the potential role of glutathione (GSH) in autism spectrum disorder
(ASD). GSH plays a key role in the detoxification of xenobiotics and maintenance of balance …
(ASD). GSH plays a key role in the detoxification of xenobiotics and maintenance of balance …