Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?

CA Akdis - Nature Reviews Immunology, 2021 - nature.com
There has been a steep increase in allergic and autoimmune diseases, reaching epidemic
proportions and now affecting more than one billion people worldwide. These diseases are …

Leaky gut: mechanisms, measurement and clinical implications in humans

M Camilleri - Gut, 2019 - gut.bmj.com
The objectives of this review on 'leaky gut'for clinicians are to discuss the components of the
intestinal barrier, the diverse measurements of intestinal permeability, their perturbation in …

Intestinal barrier in human health and disease

N Di Tommaso, A Gasbarrini, FR Ponziani - International journal of …, 2021 - mdpi.com
The intestinal mucosa provides a selective permeable barrier for nutrient absorption and
protection from external factors. It consists of epithelial cells, immune cells and their …

Intestinal barrier and permeability in health, obesity and NAFLD

P Portincasa, L Bonfrate, M Khalil, MD Angelis… - Biomedicines, 2021 - mdpi.com
The largest surface of the human body exposed to the external environment is the gut. At this
level, the intestinal barrier includes luminal microbes, the mucin layer, gastrointestinal …

Liver steatosis, gut-liver axis, microbiome and environmental factors. A never-ending bidirectional cross-talk

A Di Ciaula, J Baj, G Garruti, G Celano… - Journal of clinical …, 2020 - mdpi.com
The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide and
parallels comorbidities such as obesity, metabolic syndrome, dyslipidemia, and diabetes …

Ochratoxin A induces liver inflammation: involvement of intestinal microbiota

W Wang, S Zhai, Y **a, H Wang, D Ruan, T Zhou… - Microbiome, 2019 - Springer
Abstract Background Ochratoxin A (OTA) is a widespread mycotoxin and induces liver
inflammation to human and various species of animals. The intestinal microbiota has critical …

Gut microbiota and cardiovascular disease: evidence on the metabolic and inflammatory background of a complex relationship

A Nesci, C Carnuccio, V Ruggieri… - International Journal of …, 2023 - mdpi.com
Several studies in recent years have demonstrated that gut microbiota–host interactions play
an important role in human health and disease, including inflammatory and cardiovascular …

[HTML][HTML] Intestinal permeability in the pathogenesis of liver damage: From non-alcoholic fatty liver disease to liver transplantation

A Nicoletti, FR Ponziani, M Biolato… - World journal of …, 2019 - ncbi.nlm.nih.gov
The intimate connection and the strict mutual cooperation between the gut and the liver
realizes a functional entity called gut-liver axis. The integrity of intestinal barrier is crucial for …

Gut–liver axis: how do gut bacteria influence the liver?

PC Konturek, IA Harsch, K Konturek, M Schink… - Medical …, 2018 - mdpi.com
Chronic liver diseases are a major cause of morbidity and mortality worldwide. Recently, gut
dysbiosis was identified as an important factor in the pathogenesis of liver diseases. The …

Management of hepatorenal syndrome in liver cirrhosis: a recent update

C Bera, F Wong - Therapeutic advances in gastroenterology, 2022 - journals.sagepub.com
Hepatorenal syndrome (HRS) is a serious form of renal dysfunction in patients with cirrhosis
and ascites. It is an important component of the acute-on-chronic liver failure (ACLF) …