Upon fusion of multivesicular bodies (MVBs) with the plasma membrane, intraluminal
vesicles (ILVs) are released into the extracellular space as exosomes. Since the lipid …

About twenty years ago, the functional lipid raft model of the plasma membrane was
published. It took into account decades of research showing that cellular membranes are not …

Throughout the biological world, a 30 Å hydrophobic film typically delimits the environments
that serve as the margin between life and death for individual cells. Biochemical and …

Ceramides are involved in a variety of cellular processes and in disease. Their biological
functions are thought to depend on ceramides' unique biophysical properties, which …

Lipid membranes can spontaneously organize their components into domains of different
sizes and properties. The organization of membrane lipids into nanodomains might …

Recessive variants in GBA1 cause Gaucher disease, a prevalent form of lysosome storage
disease. GBA1 encodes a lysosomal enzyme that hydrolyzes glucosylceramide (GlcCer) …

The principles of organization and functioning of cellular membranes are currently not well
understood. The raft hypothesis suggests the existence of domains or rafts in cell …

Summary Mutations in PLA2G6 (PARK14) cause neurodegenerative disorders in humans,
including autosomal recessive neuroaxonal dystrophy and early-onset parkinsonism. We …

Membrane budding is a key step in vesicular transport, multivesicular body biogenesis, and
enveloped virus release. These events range from those that are primarily protein driven …

In the last few years several experimental strategies based on epi-, confocal and two photon
excitation fluorescence microscopy techniques have been employed to study the lateral …