The dynamic interplay between cancer and host immune system often affects the process of
myelopoiesis. As a consequence, tumor‐derived factors sustain the accumulation and …

Immune checkpoint inhibitors (ICIs) targeting PD-1 or PD-L1 have emerged as a
revolutionary treatment strategy for human cancer patients. However, as the response rate to …

Rationale: Atherosclerotic lesions are known for their cellular heterogeneity, yet the
molecular complexity within the cells of human plaques has not been fully assessed …

Intratumor heterogeneity as a clinical challenge becomes most evident after several
treatment lines, when multidrug-resistant subclones accumulate. To address this challenge …

Immune function relies on an appropriate balance of the lymphoid and myeloid responses.
In the case of neoplasia, this balance is readily perturbed by the dramatic expansion of …

Multiple myeloma (MM) is a highly refractory hematologic cancer. Targeted immunotherapy
has shown promise in MM but remains hindered by the challenge of identifying specific yet …

Single-cell RNA sequencing (scRNA-seq) is a widely used technique for characterizing
individual cells and studying gene expression at the single-cell level. Clustering plays a vital …

B-cell receptor (BCR) is a B cell hallmark surface complex regulating multiple cellular
processes in normal as well as malignant B cells. Igα (CD79a)/Igβ (CD79b) are essential …

Background Postnatal development of the mammalian mucosal immune system is crucial for
responding to the rapid colonization by commensal bacteria and possible exposure to …

Osteoarthritis (OA) is a debilitating and painful disease characterized by the progressive loss
of articular cartilage. Post‐traumatic osteoarthritis (PTOA) is an injury‐induced type of OA …