High-efficacy therapies for treatment-naïve individuals with relapsing–remitting multiple sclerosis

L Freeman, EE Longbrake, PK Coyle, B Hendin… - CNS drugs, 2022 - Springer
There are> 18 distinct disease-modifying therapy (DMT) options covering 10 mechanisms of
action currently approved by the US Food and Drug Administration for the treatment of …

Multiple sclerosis: time for early treatment with high-efficacy drugs

K Selmaj, BAC Cree, M Barnett, A Thompson… - Journal of …, 2024 - Springer
This review addresses current changes in the approach to treating patients with multiple
sclerosis (MS). The widely practiced approach of utilizing agents with lower treatment …

[HTML][HTML] Monoclonal antibodies in the treatment of relapsing multiple sclerosis: an overview with emphasis on pregnancy, vaccination, and risk management

N Krajnc, G Bsteh, T Berger, J Mares, HP Hartung - Neurotherapeutics, 2022 - Elsevier
Monoclonal antibodies have become a mainstay in the treatment of patients with relapsing
multiple sclerosis (RMS) and provide some benefit to patients with primary progressive MS …

The risk of infections for multiple sclerosis and neuromyelitis optica spectrum disorder disease-modifying treatments: Eighth European Committee for Treatment and …

C Tur, AL Dubessy, S Otero-Romero… - Multiple Sclerosis …, 2022 - journals.sagepub.com
Over the recent years, the treatment of multiple sclerosis (MS) and neuromyelitis optica
spectrum disorder (NMOSD) has evolved very rapidly and a large number of disease …

Personalized use of disease-modifying therapies in multiple sclerosis

CY Lee, KH Chan - Pharmaceutics, 2024 - mdpi.com
Multiple sclerosis is an important neurological disease affecting millions of young patients
globally. It is encouraging that more than ten disease-modifying drugs became available for …

Treatment of patients with multiple sclerosis transitioning between relapsing and progressive disease

NG Dimitriou, SG Meuth, EH Martinez-Lapiscina… - CNS drugs, 2023 - Springer
Multiple sclerosis (MS) is a chronic autoimmune demyelinating and neurodegenerative
disease of the central nervous system with a wide variety of clinical phenotypes. In spite of …

Safety and efficacy with alemtuzumab over 13 years in relapsing-remitting multiple sclerosis: final results from the open-label TOPAZ study

AJ Coles, A Achiron, A Traboulsee… - Therapeutic …, 2023 - journals.sagepub.com
Background and objectives: Alemtuzumab demonstrated superior efficacy versus
subcutaneous interferon (IFN) beta-1a in participants with relapsing-remitting multiple …

Antibody-mediated cell depletion therapies in multiple sclerosis

A Mariottini, PA Muraro, JD Lünemann - Frontiers in Immunology, 2022 - frontiersin.org
Development of disease-modifying therapies including monoclonal antibody (mAb)-based
therapeutics for the treatment of multiple sclerosis (MS) has been extremely successful over …

Expert narrative review of the safety of cladribine tablets for the management of relapsing multiple sclerosis

P Clavelou, G Castelnovo, V Pourcher, J De Sèze… - Neurology and …, 2023 - Springer
Cladribine tablets (CladT) is a highly active oral disease-modifying therapy (DMT) for the
management of relapsing multiple sclerosis (RMS). CladT acts as an immune reconstitution …

Sustained reduction of serum neurofilament light chain over 7 years by alemtuzumab in early relapsing–remitting MS

J Kuhle, N Daizadeh, P Benkert… - Multiple Sclerosis …, 2022 - journals.sagepub.com
Background: Alemtuzumab efficacy and safety was demonstrated in CARE-MS I and
extension studies (CAMMS03409; TOPAZ). Objective: Evaluate serum neurofilament light …