Cirrhosis-associated immune dysfunction
A Albillos, R Martin-Mateos, S Van der Merwe… - Nature Reviews …, 2022 - nature.com
The term cirrhosis-associated immune dysfunction (CAID) comprises the distinctive
spectrum of immune alterations associated with the course of end-stage liver disease …
spectrum of immune alterations associated with the course of end-stage liver disease …
Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance
Understanding the in vivo transport of nanoparticles provides guidelines for designing
nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of …
nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of …
Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms
S Kang, T Kishimoto - Experimental & molecular medicine, 2021 - nature.com
Abstract Interleukin-6 (IL-6) plays a crucial role in host defense against infection and tissue
injuries and is a bioindicator of multiple distinct types of cytokine storms. In this review, we …
injuries and is a bioindicator of multiple distinct types of cytokine storms. In this review, we …
Liver immunology and its role in inflammation and homeostasis
The human liver is usually perceived as a non-immunological organ engaged primarily in
metabolic, nutrient storage and detoxification activities. However, we now know that the …
metabolic, nutrient storage and detoxification activities. However, we now know that the …
[HTML][HTML] Cirrhosis-associated immune dysfunction: distinctive features and clinical relevance
A Albillos, M Lario, M Álvarez-Mon - Journal of hepatology, 2014 - Elsevier
The term cirrhosis-associated immune dysfunction refers to the main syndromic
abnormalities of immune function, immunodeficiency and systemic inflammation that are …
abnormalities of immune function, immunodeficiency and systemic inflammation that are …
Immunotherapeutic implications of IL-6 blockade for cytokine storm
T Tanaka, M Narazaki, T Kishimoto - Immunotherapy, 2016 - Taylor & Francis
IL-6 contributes to host defense against infections and tissue injuries. However,
exaggerated, excessive synthesis of IL-6 while fighting environmental stress leads to an …
exaggerated, excessive synthesis of IL-6 while fighting environmental stress leads to an …
Immune surveillance by the liver
CN Jenne, P Kubes - Nature immunology, 2013 - nature.com
Receiving both portal vein blood and arterial blood, the liver is an important and critical
component in the defense against blood-borne infection. To accomplish this role, the liver …
component in the defense against blood-borne infection. To accomplish this role, the liver …
[HTML][HTML] Bacterial infections in cirrhosis: a position statement based on the EASL Special Conference 2013
Bacterial infections are very common and represent one of the most important reasons of
progression of liver failure, development of liver-related complications, and mortality in …
progression of liver failure, development of liver-related complications, and mortality in …
Pathogenesis of liver fibrosis
Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic viral
hepatitis and, more recently, from fatty liver disease associated with obesity. Hepatic stellate …
hepatitis and, more recently, from fatty liver disease associated with obesity. Hepatic stellate …
Treatment of a metabolic liver disease by in vivo genome base editing in adult mice
L Villiger, HM Grisch-Chan, H Lindsay, F Ringnalda… - Nature medicine, 2018 - nature.com
CRISPR–Cas-based genome editing holds great promise for targeting genetic disorders,
including inborn errors of hepatocyte metabolism. Precise correction of disease-causing …
including inborn errors of hepatocyte metabolism. Precise correction of disease-causing …