Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …

The outer membrane (OM) of Gram-negative bacteria, such as Escherichia coli, is essential
for their viability. Lipopolysaccharide (LPS) constitutes the major component of OM …

Structural and functional studies of the ATP-binding cassette transporter MsbA have
revealed two distinct lipopolysaccharide (LPS) binding sites: one located in the central cavity …

Background Peptide-based vaccines have broad application prospects because of their
safety, simple preparation, and effectiveness, especially in the development of personalized …

Bacterial outer membrane (OM) is a self‐protective and permeable barrier, while having
many non‐negligible negative effects in industrial biotechnology. Our previous studies …

Lipopolysaccharide (LPS) constitutes the major component of the outer membrane and is
essential for bacteria, such as Escherichia coli. Recent work has revealed the essential roles …

Motility and biofilm formation help to protect bacteria from host immune responses and
facilitate tolerance of environmental stimuli to improve their adaptability. However, few …

Neuroinflammation is a pathophysiological condition associated with damage to the nervous
system. Maternal immune activation and early immune activation have adverse effects on …

The cell envelope of Gram-negative bacteria contains two distinct membranes, an inner (IM)
and an outer (OM) membrane, separated by the periplasm, a hydrophilic compartment that …

The complex two-membrane organization of the envelope of Gram-negative bacteria
imposes an unique biosynthetic and topological constraints that can affect translocation of …