New mutations and pathogenesis of myeloproliferative neoplasms
W Vainchenker, F Delhommeau… - Blood, The Journal …, 2011 - ashpublications.org
Myeloproliferative neoplasms (MPNs) are clonal disorders characterized by excessive
production of mature blood cells. In the majority of classic MPN—polycythemia vera …
production of mature blood cells. In the majority of classic MPN—polycythemia vera …
Genetic and epigenetic complexity in myeloproliferative neoplasms
NCP Cross - Hematology 2010, the American Society of …, 2011 - ashpublications.org
The past 7 years have witnessed remarkable progress in our understanding of the genetics
of BCR-ABL–negative myeloproliferative neoplasms (MPNs) and has revealed layers of …
of BCR-ABL–negative myeloproliferative neoplasms (MPNs) and has revealed layers of …
Complement activation in antiphospholipid syndrome and its inhibition to prevent rethrombosis after arterial surgery
Deep vein thrombosis accompanied by pulmonary embolism and thrombotic occlusion of
the cerebral and coronary arteries are common and severe complications of …
the cerebral and coronary arteries are common and severe complications of …
CALR exon 9 mutations are somatically acquired events in familial cases of essential thrombocythemia or primary myelofibrosis
E Rumi, AS Harutyunyan, D Pietra… - Blood, The Journal …, 2014 - ashpublications.org
Somatic mutations in the calreticulin (CALR) gene were recently discovered in patients with
sporadic essential thrombocythemia (ET) and primary myelofibrosis (PMF) lacking JAK2 and …
sporadic essential thrombocythemia (ET) and primary myelofibrosis (PMF) lacking JAK2 and …
Genetic and epigenetic alterations of myeloproliferative disorders
JD Milosevic, R Kralovics - International journal of hematology, 2013 - Springer
The classical BCR–ABL negative myeloproliferative neoplasms (MPN) polycythemia vera,
essential thrombocythemia, and primary myelofibrosis are clonal hematopoietic disorders …
essential thrombocythemia, and primary myelofibrosis are clonal hematopoietic disorders …
JAK2 Variant Signaling: Genetic, Hematologic and Immune Implication in Chronic Myeloproliferative Neoplasms
The JAK2 V617F variant constitutes a genetic alteration of higher frequency in BCR/ABL1
negative chronic myeloproliferative neoplasms, which is caused by a substitution of a G˃ T …
negative chronic myeloproliferative neoplasms, which is caused by a substitution of a G˃ T …
[HTML][HTML] Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome
SA Mian, AE Smith, AG Kulasekararaj, A Kizilors… - …, 2013 - ncbi.nlm.nih.gov
The recent identification of acquired mutations in key components of the spliceosome
machinery strongly implicates abnormalities of mRNA splicing in the pathogenesis of …
machinery strongly implicates abnormalities of mRNA splicing in the pathogenesis of …
The role of JAK2 inhibitors in MPNs 7 years after approval
F Passamonti, M Maffioli - Blood, The Journal of the American …, 2018 - ashpublications.org
Myeloproliferative neoplasms (MPNs) include essential thrombocythemia, polycythemia
vera (PV), and primary myelofibrosis (MF). Phenotype-driver mutations of JAK2, CALR, and …
vera (PV), and primary myelofibrosis (MF). Phenotype-driver mutations of JAK2, CALR, and …
Germline RBBP6 mutations in familial myeloproliferative neoplasms
AS Harutyunyan, R Giambruno… - Blood, The Journal …, 2016 - ashpublications.org
The retrospective nature of our study, as well as the relatively small number ofFLT3-ITD 1
AML patients included in the analysis, is the most serious limitation of the obtained data. Our …
AML patients included in the analysis, is the most serious limitation of the obtained data. Our …
Germline ATG2B/GSKIP-containing 14q32 duplication predisposes to early clonal hematopoiesis leading to myeloid neoplasms
J Pegliasco, P Hirsch, C Marzac, F Isnard, JC Meniane… - Leukemia, 2022 - nature.com
The germline predisposition associated with the autosomal dominant inheritance of the
14q32 duplication implicating ATG2B/GSKIP genes is characterized by a wide clinical …
14q32 duplication implicating ATG2B/GSKIP genes is characterized by a wide clinical …