Supramolecular amphiphiles based on host–guest molecular recognition motifs
Self-assembly, which makes use of molecules rather than atomic units, offers a bottom-up
approach to the construction of new materials on multiple length scales.(1-9) By precisely …
approach to the construction of new materials on multiple length scales.(1-9) By precisely …
Insights into RNA structure and function from genome-wide studies
SA Mortimer, MA Kidwell, JA Doudna - Nature Reviews Genetics, 2014 - nature.com
A comprehensive understanding of RNA structure will provide fundamental insights into the
cellular function of both coding and non-coding RNAs. Although many RNA structures have …
cellular function of both coding and non-coding RNAs. Although many RNA structures have …
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics
K Leppek, GW Byeon, W Kladwang… - Nature …, 2022 - nature.com
Therapeutic mRNAs and vaccines are being developed for a broad range of human
diseases, including COVID-19. However, their optimization is hindered by mRNA instability …
diseases, including COVID-19. However, their optimization is hindered by mRNA instability …
Accelerated cryo-EM-guided determination of three-dimensional RNA-only structures
The discovery and design of biologically important RNA molecules is outpacing three-
dimensional structural characterization. Here, we demonstrate that cryo-electron microscopy …
dimensional structural characterization. Here, we demonstrate that cryo-electron microscopy …
Deep learning is combined with massive-scale citizen science to improve large-scale image classification
Pattern recognition and classification of images are key challenges throughout the life
sciences. We combined two approaches for large-scale classification of fluorescence …
sciences. We combined two approaches for large-scale classification of fluorescence …
Theoretical basis for stabilizing messenger RNA through secondary structure design
RNA hydrolysis presents problems in manufacturing, long-term storage, world-wide delivery
and in vivo stability of messenger RNA (mRNA)-based vaccines and therapeutics. A largely …
and in vivo stability of messenger RNA (mRNA)-based vaccines and therapeutics. A largely …
Crowd science user contribution patterns and their implications
Scientific research performed with the involvement of the broader public (the crowd) attracts
increasing attention from scientists and policy makers. A key premise is that project …
increasing attention from scientists and policy makers. A key premise is that project …
[HTML][HTML] Host-guest chemistry in supramolecular theranostics
Macrocyclic hosts, such as cyclodextrins, calixarenes, cucurbiturils, and pillararenes, exhibit
unparalleled advantages in disease diagnosis and therapy over the past years by fully …
unparalleled advantages in disease diagnosis and therapy over the past years by fully …
A single-stranded architecture for cotranscriptional folding of RNA nanostructures
Artificial DNA and RNA structures have been used as scaffolds for a variety of nanoscale
devices. In comparison to DNA structures, RNA structures have been limited in size, but they …
devices. In comparison to DNA structures, RNA structures have been limited in size, but they …
Deep learning models for RNA secondary structure prediction (probably) do not generalize across families
Motivation The secondary structure of RNA is of importance to its function. Over the last few
years, several papers attempted to use machine learning to improve de novo RNA …
years, several papers attempted to use machine learning to improve de novo RNA …