Myricetin (MYR) is a flavonoid compound widely found in many natural plants including
bayberry. So far, MYR has been proven to have multiple biological functions and it is a …

Chemokines are a family of small, secreted cytokines which regulate a variety of cell
functions. The CXC motif chemokine ligand 12 (CXCL12) binds to CXC chemokine receptor …

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal and treatment-refractory
cancer. Molecular stratification in pancreatic cancer remains rudimentary and does not yet …

Shikonin is the major bioactive component extracted from the roots of Lithospermum
erythrorhizon which is also known as “Zicao” in Traditional Chinese Medicine (TCM). Recent …

Purpose: Early detection of pancreatic ductal adenocarcinoma (PDAC) remains elusive.
Precursor lesions of PDAC, specifically intraductal papillary mucinous neoplasms (IPMNs) …

Cancer immunotherapy has gained momentum for treating malignant tumors over the past
decade. Checkpoint blockade and chimeric antigen receptor cell therapy (CAR-T) have …

Chemokines are chemotactic cytokines that promote cancer growth, metastasis, and
regulate resistance to chemotherapy. Stromal cell-derived factor 1 (SDF1) also known as …

Anti–programmed cell death 1 ligand 1 (PD-L1) therapy is extraordinarily effective in select
patients with cancer. However, insufficient lymphocytic infiltration, weak T cell–induced …

Chemokines are small molecules called “chemotactic cytokines” and regulate many
processes like leukocyte trafficking, homing of immune cells, maturation, cytoskeletal …

Nanomedicines achieve tumor-targeted delivery mainly through enhanced permeability and
retention (EPR) effect following intravenous (IV) administration. Unfortunately, the EPR effect …