In the setting of myocardial infarction (MI), ischemia reperfusion injury (IRI) occurs due to
occlusion (ischemia) and subsequent re-establishment of blood flow (reperfusion) of a …

Transplant biologists have made significant progress over the last 20 years towards
unraveling the immunologic intricacies of allograft rejection. This large body of work has …

Acute allograft rejection requires the activation of alloreactive CD4 T cells. Despite the
capacity of B cells to act as potent APCs capable of activating CD4 T cells in vivo, their role …

BACKGROUND: Herein we study the role of donor-specific antibodies (DSA) to mismatched
human leukocyte antigen (HLA) and antibodies (Abs) to the cardiac self-antigens myosin …

Solid organ transplantation is associated with the early activation of NK cells, which are then
licensed to kill allogeneic target cells directly or via antibody-dependent cellular cytotoxicity …

OBJECTIVE: The purpose of this study was to compare the inflammatory response after
implantation of Pelvicol™ with Prolene™ in a rat model. STUDY DESIGN: Full-thickness …

Objective To compare the host response, architectural integration and tensile strength of
polypropylene and porcine small intestine submucosa‐derived implants in a rat model …

Lung transplantation is the only definitive treatment modality for many forms of end-stage
lung disease. However, the lung is rejected more often than any other type of solid organ …

A substantial proportion of long-term kidney graft recipients, including those with a stable
renal function in the absence of immunosuppressive therapy, present a skewed T cell …

Autoimmune responses to vimentin occur after solid organ transplantation, but their
pathogenic effects are unclear. The aim of these studies was to investigate the effects of …