Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders

B Dinda, S Dinda, S DasSharma, R Banik… - European journal of …, 2017 - Elsevier
Abstract The flavonoids, baicalin (5, 6-dihydroxy-2-phenyl-4H-1-benzopyran-4-one-7-Od-β-
glucuronic acid) 1 and its aglycone, baicalein 2 are found in edible medicinal plants …

Pharmacological properties of baicalin on liver diseases: a narrative review

J Yang, M Li, C Zhang, D Liu - Pharmacological Reports, 2021 - Springer
Baicalin is the main active component of Scutellaria baicalensis, widely used in traditional
Chinese medicine thanks to its various pharmacological effects, such as anti-tumor, anti …

Baicalein as a potent neuroprotective agent: A review

K Sowndhararajan, P Deepa, M Kim, SJ Park… - Biomedicine & …, 2017 - Elsevier
In recent times, neurodegenerative diseases are the most challenging global health
problems. Neuronal cell death or damage is a key factor for many neurodegenerative …

Neuroprotective and cognitive enhancement potentials of baicalin: a review

K Sowndhararajan, P Deepa, M Kim, SJ Park, S Kim - Brain Sciences, 2018 - mdpi.com
Neurodegenerative diseases are a heterogeneous group of disorders that are characterized
by the gradual loss of neurons. The development of effective neuroprotective agents to …

The benefits of flavonoids in diabetic retinopathy

AL Matos, DF Bruno, AF Ambrósio, PF Santos - Nutrients, 2020 - mdpi.com
Diabetic retinopathy (DR), one of the most common complications of diabetes, is the leading
cause of legal blindness among adults of working age in developed countries. After 20 years …

Baicalein, Baicalin, and Wogonin: Protective Effects against Ischemia‐Induced Neurodegeneration in the Brain and Retina

L Pan, KS Cho, I Yi, CH To, DF Chen… - Oxidative medicine and …, 2021 - Wiley Online Library
Ischemia is a common pathological condition present in many neurodegenerative diseases,
including ischemic stroke, retinal vascular occlusion, diabetic retinopathy, and glaucoma …

[HTML][HTML] Flavonoid-liposomes formulations: Physico-chemical characteristics, biological activities and therapeutic applications

EG Halevas, DI Avgoulas, G Katsipis… - European Journal of …, 2022 - Elsevier
Flavonoids constitute a class of naturally derived heterocyclic compounds ubiquitously
distributed in fruits, herbs and vegetables. Until today, flavonoids, as nutritional …

Treatment of glaucoma with natural products and their mechanism of action: An update

RH Sim, SR Sirasanagandla, S Das, SL Teoh - Nutrients, 2022 - mdpi.com
Glaucoma is one of the leading causes of irreversible blindness. It is generally caused by
increased intraocular pressure, which results in damage of the optic nerve and retinal …

Baicalein and Baicalin Promote Melanoma Apoptosis and Senescence via Metabolic Inhibition

L Huang, B Peng, Y Nayak, C Wang, F Si… - Frontiers in cell and …, 2020 - frontiersin.org
Malignant melanoma is one of the most common and dangerous skin cancers with a high
rate of death every year. Furthermore, N-RAS and B-RAF mutations in melanoma cells …

In vitro stabilization and in vivo improvement of ocular pharmacokinetics of the multi-therapeutic agent baicalin: Delineating the most suitable vesicular systems

O Ashraf, M Nasr, M Nebsen, AMA Said… - International journal of …, 2018 - Elsevier
Baicalin is a multi-purpose flavonoid used in the treatment of different ocular diseases.
Owing to its poor stability in basic pH and its poor solubility, a suitable carrier system is …