Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …

Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …

The present advances in biology are related to progress in genomics, proteomics, and other
“-omics”, including glycomics, working with a large amount of data regarding human and …

Electrochemical methods can be used not only for the sensitive analysis of proteins but also
for deeper research into their structure, transport functions (transfer of electrons and …

Highlights•CX-MS identifies protein–protein interactions.•Cross-linking strategies targeting
different amino acids are available.•Combining CX-MS and cryo-EM delivers high-resolution …

Parkinson's disease (PD) is characterized by intracellular, insoluble Lewy bodies composed
of highly stable α-synuclein (α-syn) amyloid fibrils. α-synuclein is an intrinsically disordered …

Neurodegenerative disorders (NDDs) are a class of debilitating diseases that progressively
impair the protein structure and result in neurological dysfunction in the nervous system …

The amyloid-β (Aβ) peptides are key molecules in Alzheimer's disease (AD) pathology. They
interact with cellular membranes, and can bind metal ions outside the membrane. Certain …

A novel electrochemical immunosensor fabricated from gold compact disc electrodes was
designed for rapid evaluation of aggregation processes that lead to the formation of …

Amyloid proteins are linked to the pathogenesis of several diseases including Alzheimer's
disease, but at the same time a range of functional amyloids are physiologically important in …