Alzheimer disease (AD) is the most common cause of dementia in older individuals. AD is
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …

The function of antibodies (Abs) involves specific binding to antigens (Ags) and activation of
other components of the immune system to fight pathogens. The six hypervariable loops …

The adaptive humoral immune response is responsible for the generation of antimicrobial
proteins known as immunoglobulin molecules or antibodies. Immunoglobulins provide a …

A central dogma in immunology is that antibody specificity is solely the result of variable (V)-
region interactions with an antigen. However, this view is not tenable in light of numerous …

Numerous monoclonal antibodies have been developed successfully for the treatment of
various diseases. Nevertheless, the development of biotherapeutic antibodies is complex …

The constant heavy chain (CH1) domain affects antibody affinity and fine specificity,
challenging the paradigm that only variable regions contribute to antigen binding. To …

To study structural changes that occur in Abs upon Ag binding, we systematically compared
free and bound structures of all 141 crystal structures of the 49 Abs that were solved in these …

ABSTRACT A key question in immunology is whether antigen recognition and Fc receptor
(FcR) binding are allosterically linked. This question is also relevant for therapeutic antibody …

ABSTRACT A central dogma in immunology is that an antibody's in vivo functionality is
mediated by 2 independent events: antigen binding by the variable (V) region, followed by …

Background Eleven tau immunoglobulin G (IgG) antibodies have entered clinical trials to
treat tauopathies, including Alzheimer's disease, but it is unclear which IgG …