The pleiotropic functions of reactive oxygen species in cancer
K Wu, AE El Zowalaty, VI Sayin… - Nature Cancer, 2024 - nature.com
Cellular redox homeostasis is an essential, dynamic process that ensures the balance
between reducing and oxidizing reactions within cells and thus has implications across all …
between reducing and oxidizing reactions within cells and thus has implications across all …
Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
Abstract 'Reactive oxygen species'(ROS) is a generic term that defines a wide variety of
oxidant molecules with vastly different properties and biological functions that range from …
oxidant molecules with vastly different properties and biological functions that range from …
Vitamin A-retinoic acid signaling regulates hematopoietic stem cell dormancy
N Cabezas-Wallscheid, F Buettner, P Sommerkamp… - Cell, 2017 - cell.com
Dormant hematopoietic stem cells (dHSCs) are atop the hematopoietic hierarchy. The
molecular identity of dHSCs and the mechanisms regulating their maintenance or exit from …
molecular identity of dHSCs and the mechanisms regulating their maintenance or exit from …
Deciphering the mechanism of glutaredoxin-catalyzed roGFP2 redox sensing reveals a ternary complex with glutathione for protein disulfide reduction
F Geissel, L Lang, B Husemann, B Morgan… - Nature …, 2024 - nature.com
Glutaredoxins catalyze the reduction of disulfides and are key players in redox metabolism
and regulation. While important insights were gained regarding the reduction of glutathione …
and regulation. While important insights were gained regarding the reduction of glutathione …
[HTML][HTML] European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …
Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise
Reactive oxygen species (ROS) act as intracellular compartmentalized second messengers,
mediating metabolic stress-adaptation. In skeletal muscle fibers, ROS have been suggested …
mediating metabolic stress-adaptation. In skeletal muscle fibers, ROS have been suggested …
Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity
K Schönberger, N Obier, MC Romero-Mulero… - Cell stem cell, 2022 - cell.com
Hematopoietic stem cells (HSCs) rely on complex regulatory networks to preserve stemness.
Due to the scarcity of HSCs, technical challenges have limited our insights into the interplay …
Due to the scarcity of HSCs, technical challenges have limited our insights into the interplay …
[HTML][HTML] Self-sustaining long-term 3D epithelioid cultures reveal drivers of clonal expansion in esophageal epithelium
Aging epithelia are colonized by somatic mutations, which are subjected to selection
influenced by intrinsic and extrinsic factors. The lack of suitable culture systems has slowed …
influenced by intrinsic and extrinsic factors. The lack of suitable culture systems has slowed …
Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells
Skeletal muscle has long been recognized as an inhospitable site for disseminated tumour
cells (DTCs). Yet its antimetastatic nature has eluded a thorough mechanistic examination …
cells (DTCs). Yet its antimetastatic nature has eluded a thorough mechanistic examination …
Improvement of islet transplantation by the fusion of islet cells with functional blood vessels
Pancreatic islet transplantation still represents a promising therapeutic strategy for curative
treatment of type 1 diabetes mellitus. However, a limited number of organ donors and …
treatment of type 1 diabetes mellitus. However, a limited number of organ donors and …