Tumour hypoxia has been pursued as a cancer drug target for over 30 years, most notably
using bioreductive (hypoxia-activated) prodrugs that target antineoplastic agents to low …

The rationale for the development of prodrugs relies upon delivery of higher concentrations
of a drug to target cells compared to administration of the drug itself. In the last decades …

Quinones are a class of natural and synthetic compounds that have several beneficial
effects. Quinones are electron carriers playing a role in photosynthesis. As vitamins, they …

Hypoxia-activated prodrugs (HAPs) are designed to specifically target the hypoxic cells of
tumors, which are an important cause of treatment resistance to conventional therapies …

Systemic cytotoxic (anti-proliferative) anticancer drugs rely primarily for their therapeutic
effect on cytokinetic differences between cancer and normal cells. One approach aimed at …

Hypoxia, a state of low oxygen, is a common feature of solid tumors and is associated with
disease progression as well as resistance to radiotherapy and certain chemotherapeutic …

Abstract TH-302 is a 2-nitroimidazole triggered hypoxia-activated prodrug (HAP) of bromo-
isophosphoramide mustard currently undergoing clinical evaluation. Here, we describe …

Quinoxaline 1, 4-di-N-oxides (QdNOs) have manifold biological properties, including
antimicrobial, antitumoral, antitrypanosomal and antiinflammatory/antioxidant activities …

Cancer cells in hypoxic areas of solid tumors are to a large extent protected against the
action of radiation as well as many chemotherapeutic drugs. There are, however, two …

One of the key issues for radiobiologists is the importance of hypoxia to the radiotherapy
response. This review addresses the reasons for this and primarily focuses on one aspect …