The spliceosome removes introns from messenger RNA precursors (pre-mRNA). Decades
of biochemistry and genetics combined with recent structural studies of the spliceosome …

Recent advances in pseudouridine detection reveal a complex pseudouridine landscape
that includes messenger RNA and diverse classes of noncoding RNA in human cells. The …

Rapid protein degradation enables cells to quickly modulate protein abundance.
Dysregulation of short-lived proteins plays essential roles in disease pathogenesis. A …

Tau aggregates contribute to neurodegenerative diseases, including frontotemporal
dementia and Alzheimer's disease (AD). Although RNA promotes tau aggregation in vitro …

The spliceosome is a highly complex, dynamic ribonucleoprotein molecular machine that
undergoes numerous structural and compositional rearrangements that lead to the formation …

RNA splicing, the process of intron removal from pre-mRNA, is essential for the regulation of
gene expression. It is controlled by the spliceosome, a megadalton RNA–protein complex …

Viruses are highly dependent on the host they infect. Their dependence triggers processes
of virus–host co-adaptation, enabling viruses to explore host resources whilst esca** …

Small nuclear RNAs (snRNAs) are critical components of the spliceosome that catalyze the
splicing of pre-mRNA. snRNAs are each complexed with many proteins to form RNA-protein …

Glioblastoma (GBM) is the most lethal type of primary brain cancer. Standard care using
chemo-and radio-therapy modestly increases the overall survival of patients; however …

Abstract Three RNA helicases–DDX42, DDX46 and DHX15–are found to be associated with
human U2 snRNP, but their roles and mechanisms in U2 snRNP and spliceosome assembly …