Phosphorylation offers a dynamic way to regulate protein activity and subcellular
localization, which is achieved through its reversibility and fast kinetics. Adding or removing …

The structure of chromatin, affected by many factors from DNA linker lengths to
posttranslational modifications, is crucial to the regulation of eukaryotic cells. Combined …

Histone tails harbor a plethora of post-translational modifications that direct the function of
chromatin regulators, which recognize them through effector domains. Effector …

Histone tails and their epigenetic modifications play crucial roles in gene expression
regulation by altering the architecture of chromatin. However, the structural mechanisms by …

Resveratrol is a natural compound found in red wine that has been suggested to exert its
potential health benefit through the activation of SIRT1, a crucial member of the mammalian …

The TMPRSS2-ERG gene fusion is the most frequent alteration observed in human prostate
cancer. However, its role in disease progression is still unclear. In this study, we uncover an …

Cytosolic phosphoenolpyruvate carboxykinase (PCK1) is considered a gluconeogenic
enzyme; however, its metabolic functions and regulatory mechanisms beyond …

Background: Even though liver kinase B1 (LKB1) is usually described as a tumor suppressor
in a wide variety of tissues, it has been shown that LKB1 aberrant expression is associated …

Epigenetic modifications of histone N-terminal tails play a critical role in regulating the
chromatin structure and biological processes such as transcription and DNA repair. One of …

Sirtuins are key regulators of many cellular functions including cell growth, apoptosis,
metabolism, and genetic control of age-related diseases. Sirtuins are themselves regulated …