Antibiotics are the commonest cause of life-threatening immune-mediated drug reactions
that are considered off-target, including anaphylaxis, and organ-specific and severe …

Importance β-Lactam antibiotics are among the safest and most effective antibiotics. Many
patients report allergies to these drugs that limit their use, resulting in the use of broad …

Background A reported penicillin allergy may compromise receipt of recommended
antibiotic prophylaxis intended to prevent surgical site infections (SSIs). Most patients with a …

Allergists and clinical immunologists around the world are increasingly faced with the task of
addressing drug allergy and hypersensitivity due to the increase in drug reactions …

Objective To evaluate the relation between penicillin allergy and development of meticillin
resistant Staphylococcus aureus (MRSA) and C difficile. Design Population based matched …

Penicillin Allergy Many more patients are labeled as penicillin-allergic than actually are
allergic. The label should be analyzed with skin testing and test exposure. Patients with true …

Abstract Background Even though 8%‐25% of most populations studied globally are labeled
as penicillin allergic, most diagnoses of penicillin allergy are made in childhood and relate …

β-Lactam drugs (penicillins, amoxicillin, and cephalosporins) account for 42.6% of all severe
drug-induced anaphylaxis. In this review, we focus on clinically significant immunologic …

Penicillin allergy is often diagnosed early in life, and the history of penicillin allergy persists
in a patient's medical record for many years without verification. Some physicians' …

The penicillin allergy label has been consistently linked with deleterious effects that span the
health care spectrum, including suboptimal clinical outcomes, the emergence of bacterial …