Cortical neuromodulatory transmitter systems refer to those classical neurotransmitters such
as acetylcholine and monoamines, which share a number of common features. For instance …

In addition to being a key component of the autonomic nervous system, acetylcholine acts as
a prominent neurotransmitter and neuromodulator upon release from key groups of …

Abstract Representations of sensory stimuli in the cerebral cortex can undergo progressive
remodelling according to the behavioural importance of the stimuli,. The cortex receives …

Pathological neural activity in a variety of neurological disorders could be treated by
directing plasticity to specifically renormalize aberrant neural circuits, thereby restoring …

The contribution of the basal forebrain cholinergic system in mediating plasticity of cortical
sensorimotor representations was examined in the context of normal learning. The effects of …

Studies of the function of the basal forebrain have focused on cholinergic neurons that
project to cortical and limbic structures critical for various cognitive abilities. Recent …

Cortical map plasticity is believed to be a key substrate of perceptual and skill learning. In
the current study, we quantified changes in perceptual ability after pairing tones with …

Neurons in rodent primary visual cortex (V1) relate operantly conditioned stimulus-reward
intervals with modulated patterns of spiking output, but little is known about the locus or …

In a slice preparation of rat visual cortex, we discovered that paired-pulse stimulation (PPS)
elicits a form of homosynaptic long-term depression (LTD) in the superficial layers when …

Upper limb impairment is a common debilitating consequence of ischemic stroke. Physical
rehabilitation after stroke enhances neuroplasticity and improves limb function, but does not …