Wnt and PI3K/Akt/mTOR survival pathways as therapeutic targets in glioblastoma

A Barzegar Behrooz, Z Talaie, F Jusheghani… - International journal of …, 2022 - mdpi.com
Glioblastoma (GBM) is a devastating type of brain tumor, and current therapeutic treatments,
including surgery, chemotherapy, and radiation, are palliative at best. The design of effective …

Mechanisms of resistance and current treatment options for glioblastoma multiforme (GBM)

SSK Yalamarty, N Filipczak, X Li, MA Subhan… - Cancers, 2023 - mdpi.com
Simple Summary Glioblastoma multiforme is one of the hardest-to-treat brain tumors, often
resistant to conventional treatments such as chemotherapy and radiation therapy. Despite …

Macrophage membrane-camouflaged responsive polymer nanogels enable magnetic resonance imaging-guided chemotherapy/chemodynamic therapy of orthotopic …

T **ao, M He, F Xu, Y Fan, B Jia, M Shen, H Wang… - ACS …, 2021 - ACS Publications
Development of innovative nanomedicine formulations to traverse the blood–brain barrier
(BBB) for effective theranostics of glioma remains a great challenge. Herein, we report the …

Nanosensitizers for sonodynamic therapy for glioblastoma multiforme: current progress and future perspectives

QL Guo, XL Dai, MY Yin, HW Cheng, HS Qian… - Military Medical …, 2022 - Springer
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor, and it is
associated with poor prognosis. Its characteristics of being highly invasive and undergoing …

METTL3-mediated m6A modification of LINC00839 maintains glioma stem cells and radiation resistance by activating Wnt/β-catenin signaling

J Yin, F Ding, Z Cheng, X Ge, Y Li, A Zeng… - Cell death & …, 2023 - nature.com
Long noncoding RNAs (lncRNAs) are involved in glioma initiation and progression. Glioma
stem cells (GSCs) are essential for tumor initiation, maintenance, and therapeutic resistance …

Functionalized nanomaterials capable of crossing the blood–brain barrier

S Zha, H Liu, H Li, H Li, KL Wong, AH All - ACS nano, 2024 - ACS Publications
The blood–brain barrier (BBB) is a specialized semipermeable structure that highly
regulates exchanges between the central nervous system parenchyma and blood vessels …

Signaling pathways and therapeutic approaches in glioblastoma multiforme

M Khabibov, A Garifullin… - International …, 2022 - spandidos-publications.com
Glioblastoma multiforme (GBM) is the most aggressive type of primary brain tumor and is
associated with a poor clinical prognosis. Despite the progress in the understanding of the …

Advances in glioblastoma therapy: an update on current approaches

RS Angom, NMR Nakka, S Bhattacharya - Brain sciences, 2023 - mdpi.com
Glioblastoma multiforme (GBM) is a primary malignant brain tumor characterized by a high
grade of malignancy and an extremely unfavorable prognosis. The current efficacy of …

Cytotoxic effect of diferuloylmethane, a derivative of turmeric on different human glioblastoma cell lines

I Bilal, S **e, MS Elburki, Z Aziziaram… - Cellular, Molecular …, 2021 - cmbr-journal.com
Glioblastoma is a fatal brain tumor, and the standard treatment for this cancer is the surgical
removal of the tumor followed by chemotherapy with temozolomide and radiotherapy …

Nanotechnology meets glioblastoma multiforme: Emerging therapeutic strategies

D Liu, X Dai, L Ye, H Wang, H Qian… - Wiley …, 2023 - Wiley Online Library
Glioblastoma multiforme (GBM) represents the most common and fatal form of primary
invasive brain tumors as it affects a great number of patients each year and has a median …