Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two
types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research …

One of the main engines that drives cellular transformation is the loss of proper control of the
mammalian cell cycle. The cyclin-dependent kinase inhibitor p21 (also known as …

The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …

One of the major problems in management of prostate cancer is the lack of reliable genetic
markers predicting the clinical course of the disease. We analyzed expression profiles of …

Although prostate cancer is the most common malignancy to affect men in the Western
world, the molecular mechanisms underlying its development and progression remain …

Abstract KLF5 (Kruppel-like factor 5) is a basic transcription factor binding to GC boxes at a
number of gene promoters and regulating their transcription. KLF5 is expressed during …

Krüppel-like factors (KLFs) are a family of zinc-finger transcription factors that are found in
many species. Recent studies have shown that KLFs play a fundamental role in regulating …

Quantitative and structural genetic alterations cause the development and progression of
prostate cancer. A number of genes have been implicated in prostate cancer by genetic …

Prostate cancer is a leading and increasingly prevalent cause of cancer death in men.
Whereas family history of disease is one of the strongest prostate cancer risk factors and …

Zinc is a trace mineral which is vital for the functioning of numerous cellular processes, is
critical for growth, and may play an important role in cancer etiology and outcome. The …