Anti-inflammatory drugs as anticancer agents

S Zappavigna, AM Cossu, A Grimaldi… - International journal of …, 2020 - mdpi.com
Inflammation is strictly associated with cancer and plays a key role in tumor development
and progression. Several epidemiological studies have demonstrated that inflammation can …

Roles of NF-κB in cancer and inflammatory diseases and their therapeutic approaches

MH Park, JT Hong - Cells, 2016 - mdpi.com
Nuclear factor-κB (NF-κB) is a transcription factor that plays a crucial role in various
biological processes, including immune response, inflammation, cell growth and survival …

[HTML][HTML] Aspirin Use, Tumor PIK3CA Mutation, and Colorectal-Cancer Survival

X Liao, P Lochhead, R Nishihara… - … England Journal of …, 2012 - Mass Medical Soc
Background Regular use of aspirin after a diagnosis of colon cancer has been associated
with a superior clinical outcome. Experimental evidence suggests that inhibition of …

Inhibiting NF-κB activation by small molecules as a therapeutic strategy

SC Gupta, C Sundaram, S Reuter… - Biochimica et Biophysica …, 2010 - Elsevier
Because nuclear factor-κB (NF-κB) is a ubiquitously expressed proinflammatory transcription
factor that regulates the expression of over 500 genes involved in cellular transformation …

Inflammation, NF-κB, and chronic diseases: how are they linked?

AB Kunnumakkara, B Shabnam, S Girisa… - Critical Reviews™ in …, 2020 - dl.begellhouse.com
Most chronic diseases, caused by lifestyle factors, appear to be linked to inflammation.
Inflammation is activated mechanistically, and nuclear factor-κB (NF-κB) is a significant …

[HTML][HTML] Anti-inflammatory agents for cancer therapy

ER Rayburn, SJ Ezell, R Zhang - Molecular and cellular …, 2009 - ncbi.nlm.nih.gov
Inflammation is closely linked to cancer, and many anti-cancer agents are also used to treat
inflammatory diseases, such as rheumatoid arthritis. Moreover, chronic inflammation …

Molecular targets of aspirin and cancer prevention

L Alfonso, G Ai, RC Spitale, GJ Bhat - British journal of cancer, 2014 - nature.com
Salicylates from plant sources have been used for centuries by different cultures to treat a
variety of ailments such as inflammation, fever and pain. A chemical derivative of salicylic …

cellular and molecular mechanisms of NSAID‐induced peptic ulcers

C Musumba, DM Pritchard… - Alimentary …, 2009 - Wiley Online Library
Background Nonsteroidal anti‐inflammatory drugs (NSAIDs) are some of the most
prescribed drugs worldwide and have now probably overtaken Helicobacter pylori as the …

Evaluation of PIK3CA Mutation As a Predictor of Benefit From Nonsteroidal Anti-Inflammatory Drug Therapy in Colorectal Cancer

E Domingo, DN Church, O Sieber… - Journal of clinical …, 2013 - ascopubs.org
Purpose Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) protect against
colorectal cancer (CRC) and are associated with reduced disease recurrence and improved …

Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis

J Prause, A Goswami, I Katona, A Roos… - Human molecular …, 2013 - academic.oup.com
Intracellular accumulations of mutant, misfolded proteins are major pathological hallmarks of
amyotrophic lateral sclerosis (ALS) and related disorders. Recently, mutations in Sigma …