Anti-inflammatory drugs as anticancer agents
S Zappavigna, AM Cossu, A Grimaldi… - International journal of …, 2020 - mdpi.com
Inflammation is strictly associated with cancer and plays a key role in tumor development
and progression. Several epidemiological studies have demonstrated that inflammation can …
and progression. Several epidemiological studies have demonstrated that inflammation can …
Roles of NF-κB in cancer and inflammatory diseases and their therapeutic approaches
MH Park, JT Hong - Cells, 2016 - mdpi.com
Nuclear factor-κB (NF-κB) is a transcription factor that plays a crucial role in various
biological processes, including immune response, inflammation, cell growth and survival …
biological processes, including immune response, inflammation, cell growth and survival …
[HTML][HTML] Aspirin Use, Tumor PIK3CA Mutation, and Colorectal-Cancer Survival
X Liao, P Lochhead, R Nishihara… - … England Journal of …, 2012 - Mass Medical Soc
Background Regular use of aspirin after a diagnosis of colon cancer has been associated
with a superior clinical outcome. Experimental evidence suggests that inhibition of …
with a superior clinical outcome. Experimental evidence suggests that inhibition of …
Inhibiting NF-κB activation by small molecules as a therapeutic strategy
SC Gupta, C Sundaram, S Reuter… - Biochimica et Biophysica …, 2010 - Elsevier
Because nuclear factor-κB (NF-κB) is a ubiquitously expressed proinflammatory transcription
factor that regulates the expression of over 500 genes involved in cellular transformation …
factor that regulates the expression of over 500 genes involved in cellular transformation …
Inflammation, NF-κB, and chronic diseases: how are they linked?
Most chronic diseases, caused by lifestyle factors, appear to be linked to inflammation.
Inflammation is activated mechanistically, and nuclear factor-κB (NF-κB) is a significant …
Inflammation is activated mechanistically, and nuclear factor-κB (NF-κB) is a significant …
[HTML][HTML] Anti-inflammatory agents for cancer therapy
ER Rayburn, SJ Ezell, R Zhang - Molecular and cellular …, 2009 - ncbi.nlm.nih.gov
Inflammation is closely linked to cancer, and many anti-cancer agents are also used to treat
inflammatory diseases, such as rheumatoid arthritis. Moreover, chronic inflammation …
inflammatory diseases, such as rheumatoid arthritis. Moreover, chronic inflammation …
Molecular targets of aspirin and cancer prevention
Salicylates from plant sources have been used for centuries by different cultures to treat a
variety of ailments such as inflammation, fever and pain. A chemical derivative of salicylic …
variety of ailments such as inflammation, fever and pain. A chemical derivative of salicylic …
cellular and molecular mechanisms of NSAID‐induced peptic ulcers
C Musumba, DM Pritchard… - Alimentary …, 2009 - Wiley Online Library
Background Nonsteroidal anti‐inflammatory drugs (NSAIDs) are some of the most
prescribed drugs worldwide and have now probably overtaken Helicobacter pylori as the …
prescribed drugs worldwide and have now probably overtaken Helicobacter pylori as the …
Evaluation of PIK3CA Mutation As a Predictor of Benefit From Nonsteroidal Anti-Inflammatory Drug Therapy in Colorectal Cancer
Purpose Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) protect against
colorectal cancer (CRC) and are associated with reduced disease recurrence and improved …
colorectal cancer (CRC) and are associated with reduced disease recurrence and improved …
Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis
Intracellular accumulations of mutant, misfolded proteins are major pathological hallmarks of
amyotrophic lateral sclerosis (ALS) and related disorders. Recently, mutations in Sigma …
amyotrophic lateral sclerosis (ALS) and related disorders. Recently, mutations in Sigma …