Importance Observational (nonexperimental) studies that aim to emulate a randomized trial
(ie, the target trial) are increasingly informing medical and policy decision-making, but it is …

Purpose To identify the proportion of patients with continued opioid use after total hip or
knee arthroplasty. Methods This systematic review and meta-analysis searched Embase …

Background Data sharing is considered a crucial part of modern medical research.
Unfortunately, despite its advantages, it often faces obstacles, especially data privacy …

There is growing interest in using observational data to assess the safety, effectiveness, and
cost effectiveness of medical technologies, but operational, technical, and methodological …

Confounding remains one of the major challenges to causal inference with observational
data. This problem is paramount in medicine, where we would like to answer causal …

Knee replacement surgery confronts challenges including patient dissatisfaction and the
necessity for secondary procedures. A key requirement lies in dual‐modal measurement of …

Background and objective As a response to the ongoing COVID-19 pandemic, several
prediction models in the existing literature were rapidly developed, with the aim of providing …

Importance State cannabis laws are changing rapidly. Research is inconclusive about their
association with rates of self-harm and assault. Existing studies have not considered …

Objectives Target trial emulation is an intuitive design framework that encourages
investigators to formulate their comparative effectiveness research (CER) question as a …

Traditionally, medical research is based on randomized controlled trials (RCTs) for
interventions such as drugs and operative procedures. However, increasingly, there is a …