Two decades of Martini: Better beads, broader scope

SJ Marrink, L Monticelli, MN Melo… - Wiley …, 2023 - Wiley Online Library
The Martini model, a coarse‐grained force field for molecular dynamics simulations, has
been around for nearly two decades. Originally developed for lipid‐based systems by the …

Pragmatic coarse-graining of proteins: models and applications

L Borges-Araújo, I Patmanidis, AP Singh… - Journal of Chemical …, 2023 - ACS Publications
The molecular details involved in the folding, dynamics, organization, and interaction of
proteins with other molecules are often difficult to assess by experimental techniques …

The SIRAH force field: a suite for simulations of complex biological systems at the coarse-grained and multiscale levels

F Klein, M Soñora, LH Santos, EN Frigini… - Journal of structural …, 2023 - Elsevier
The different combinations of molecular dynamics simulations with coarse-grained
representations have acquired considerable popularity among the scientific community …

Application of computational approaches in biomembranes: From structure to function

J Guo, Y Bao, M Li, S Li, L **, P **n… - Wiley …, 2023 - Wiley Online Library
Biological membranes (biomembranes) are one of the most complicated structures that
allow life to exist. Investigating their structure, dynamics, and function is crucial for advancing …

SPICA force field for proteins and peptides

S Kawamoto, H Liu, Y Miyazaki, S Seo… - Journal of Chemical …, 2022 - ACS Publications
A coarse-grained (CG) model for peptides and proteins was developed as an extension of
the Surface Property fItting Coarse grAined (SPICA) force field (FF). The model was …

Specific interactions of peripheral membrane proteins with lipids: what can molecular simulations show us?

AH Larsen, LH John, MSP Sansom… - Bioscience …, 2022 - portlandpress.com
Peripheral membrane proteins (PMPs) can reversibly and specifically bind to biological
membranes to carry out functions such as cell signalling, enzymatic activity, or membrane …

The role of transmembrane proteins in plant growth, development, and stress responses

Y Zhou, B Wang, F Yuan - International Journal of Molecular Sciences, 2022 - mdpi.com
Transmembrane proteins participate in various physiological activities in plants, including
signal transduction, substance transport, and energy conversion. Although more than 20 …

Capturing choline–aromatics cation− π interactions in the MARTINI force field

HM Khan, PCT Souza, S Thallmair… - Journal of chemical …, 2020 - ACS Publications
Cation− π interactions play an important role in biomolecular recognition, including
interactions between membrane phosphatidylcholine lipids and aromatic amino acids of …

A data-driven dimensionality reduction approach to compare and classify lipid force fields

R Capelli, A Gardin, C Empereur-Mot… - The Journal of …, 2021 - ACS Publications
Molecular dynamics simulations of all-atom and coarse-grained lipid bilayer models are
increasingly used to obtain useful insights for understanding the structural dynamics of these …

LipIDens: simulation assisted interpretation of lipid densities in cryo-EM structures of membrane proteins

TB Ansell, W Song, CE Coupland, L Carrique… - Nature …, 2023 - nature.com
Cryo-electron microscopy (cryo-EM) enables the determination of membrane protein
structures in native-like environments. Characterising how membrane proteins interact with …