Virus entry, consisting of attachment to and penetration into the host target cell, is the first
step of the virus life cycle and is a critical 'do or die'event that governs virus emergence in …

Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) can restrict viral pathogens,
but pro-and anti-viral activities have been reported for coronaviruses. Here, we show that …

S-Acylation (commonly referred to as S-palmitoylation) is a post-translational modification
consisting in the covalent attachment of an acyl chain to a cysteine residue of the target …

Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) have emerged as important
innate immune effectors that prevent diverse virus infections in vertebrates. However, the …

Esophageal squamous cell carcinoma (ESCC) is prevalent in some geographical regions of
the world. ESCC development presents a multistep pathogenic process from inflammation to …

Multiple sclerosis (MS) is the most common chronic central nervous system inflammatory
disease. Individual courses are highly variable, with complete remission in some patients …

Fatty acylation of cysteine residues provides spatial and temporal control of protein function
in cells and regulates important biological pathways in eukaryotes. Although recent methods …

Interferons (IFNs) are important cytokines that regulate immune responses through the
activation of hundreds of genes, including interferon-induced transmembrane proteins …

The first responders of human antiviral immunity are components of the intrinsic immune
response that reside within each and every one of our cells. This cell-autonomous arsenal …

Simple Summary Novel therapeutic targets are needed to improve treatments of aggressive
cancers and viral diseases. Tetraspanins represent an emerging class of anticancer targets …