The global burden of fungal disease poses a substantial threat to human, animal, and
environmental health, endangering both human and livestock populations and creating …

The emergence of new fungal pathogens makes the development of new antifungal drugs a
medical imperative that in recent years motivates the talents of numerous investigators …

Reaction predictor is an application for predicting chemical reactions and reaction pathways.
It uses deep learning to predict and rank elementary reactions by first identifying electron …

Malaria remains one of the most deadly infectious diseases globally. Considering the
growing spread of resistance, development of new and effective antimalarials remains an …

Fungal infections impact the lives of at least 12 million people every year, killing over 1.5
million. Wide-spread use of fungicides and prophylactic antifungal therapy have driven …

In the recent past, prevalence of life threatening fungal diseases have increased rapidly in
immune-compromised cases such as acquired immunodeficiency syndrome (AIDS), cancer …

A series of carbazole-triazole conjugates were designed, synthesized and characterized by
IR, NMR, and HRMS spectra. Biological assay showed that most of the synthesized …

Epoxides as alkylating reagents are unprecedentedly applied in Pd (II)-catalyzed C–H
alkylation and oxidative annulation of substituted benzamides to synthesize isoquinolones …

Phthalazine derivatives have recently received a lot of interest in the realm of physiologically
active chemical research. Introduce this phthalazine moiety to a researcher in a new …

Effective strategies are needed to deal with invasive fungal infections caused by drug-
resistant fungi. Previously, we designed a series of antifungal benzocyclane derivatives …