Molecular diagnostics is becoming one of the major drivers of personalized oncology. With
hundreds of different approved anticancer drugs and regimens of their administration …

Members of the EGFR family of tyrosine kinase receptors are major regulators of cellular
proliferation, differentiation, and survival. In humans, abnormal activation of EGFR is …

Current methods of high-throughput molecular and genomic analyses enabled to
reconstruct thousands of human molecular pathways. Knowledge of molecular pathways …

Background: Inevitable recurrence after radiochemotherapy is the major problem in the
treatment of glioblastoma, the most prevalent type of adult brain malignancy. Glioblastomas …

Gastric cancer (GC) is the fifth-ranked cancer type by associated mortality. The proportion of
early diagnosis is low, and most patients are diagnosed at the advanced stages. First-line …

Background: Glioblastoma (GBM) is the most aggressive and lethal central nervous system
(CNS) tumor. The treatment strategy is mainly surgery and/or radiation therapy, both …

(1) Background: Emergence of methods interrogating gene expression at high throughput
gave birth to quantitative transcriptomics, but also posed a question of inter-comparison of …

Abstract Analysis of molecular pathway activation is the recent instrument that helps to
quantize activities of various intracellular signaling, structural, DNA synthesis and repair …

Introduction: Co-normalization of RNA profiles obtained using different experimental
platforms and protocols opens avenue for comprehensive comparison of relevant features …

Background: Overall survival of advanced colorectal cancer (CRC) patients remains poor,
and gene expression analysis could potentially complement detection of clinically relevant …