A review on possible mechanistic insights of Nitazoxanide for repurposing in COVID-19
The global pandemic of Coronavirus Disease 2019 (COVID-19) has brought the world to a
grinding halt. A major cause of concern is the respiratory distress associated mortality …
grinding halt. A major cause of concern is the respiratory distress associated mortality …
Intracellular Sources of ROS/H2O2 in Health and Neurodegeneration: Spotlight on Endoplasmic Reticulum
Reactive oxygen species (ROS) are produced continuously throughout the cell as products
of various redox reactions. Yet these products function as important signal messengers …
of various redox reactions. Yet these products function as important signal messengers …
[HTML][HTML] Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
M Pajares, A Cuadrado, AI Rojo - Redox biology, 2017 - Elsevier
Neurodegenerative diseases are linked to the accumulation of specific protein aggregates,
suggesting an intimate connection between injured brain and loss of proteostasis …
suggesting an intimate connection between injured brain and loss of proteostasis …
ER stress and impaired autophagy flux in neuronal degeneration and brain injury
Autophagy is a highly controlled lysosome-mediated function in eukaryotic cells to eliminate
damaged or aged long-lived proteins and organelles. It is required for restoring cellular …
damaged or aged long-lived proteins and organelles. It is required for restoring cellular …
Protein disulphide isomerase inhibition as a potential cancer therapeutic strategy
LE Powell, PA Foster - Cancer medicine, 2021 - Wiley Online Library
The protein disulphide isomerase (PDI) gene family is a large, diverse group of enzymes
recognised for their roles in disulphide bond formation within the endoplasmic reticulum …
recognised for their roles in disulphide bond formation within the endoplasmic reticulum …
[HTML][HTML] Emerging roles of protein disulfide isomerase in cancer
E Lee - BMB reports, 2017 - ncbi.nlm.nih.gov
The protein disulfide isomerase (PDI) family is a group of multifunctional endoplasmic
reticulum (ER) enzymes that mediate the formation of disulfide bonds, catalyze the cysteine …
reticulum (ER) enzymes that mediate the formation of disulfide bonds, catalyze the cysteine …
Thiamine deficiency and neurodegeneration: the interplay among oxidative stress, endoplasmic reticulum stress, and autophagy
Thiamine (vitamin B1) is an essential nutrient and indispensable for normal growth and
development of the organism due to its multilateral participation in key biochemical and …
development of the organism due to its multilateral participation in key biochemical and …
The difference of physiological and proteomic changes in maize leaves adaptation to drought, heat, and combined both stresses
F Zhao, D Zhang, Y Zhao, W Wang, H Yang… - Frontiers in plant …, 2016 - frontiersin.org
At the eight-leaf stage, maize is highly sensitive to stresses such as drought, heat, and their
combination, which greatly affect its yield. At present, few studies have analyzed maize …
combination, which greatly affect its yield. At present, few studies have analyzed maize …
[HTML][HTML] PDIA3: Structure, functions and its potential role in viral infections
The catalysis of disulphide (single bondSsingle bondSsingle bond) bonds is the most
important characteristic of protein disulphide isomerase (PDI) family. Catalysis occurs in the …
important characteristic of protein disulphide isomerase (PDI) family. Catalysis occurs in the …
Unfolded protein response as a compensatory mechanism and potential therapeutic target in PLN R14del cardiomyopathy
Background: Phospholamban (PLN) is a critical regulator of calcium cycling and contractility
in the heart. The loss of arginine at position 14 in PLN (R14del) is associated with dilated …
in the heart. The loss of arginine at position 14 in PLN (R14del) is associated with dilated …