Multitarget approaches against multiresistant superbugs

DA Gray, M Wenzel - ACS infectious diseases, 2020 - ACS Publications
Despite efforts to develop new antibiotics, antibacterial resistance still develops too fast for
drug discovery to keep pace. Often, resistance against a new drug develops even before it …

Clofazimine for the treatment of tuberculosis

JAM Stadler, G Maartens, G Meintjes… - Frontiers in …, 2023 - frontiersin.org
Shorter (6–9 months), fully oral regimens containing new and repurposed drugs are now the
first-choice option for the treatment of drug-resistant tuberculosis (DR-TB). Clofazimine, long …

Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19

C Mirabelli, JW Wotring, CJ Zhang, SM McCarty… - Proceedings of the …, 2021 - pnas.org
The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
and the associated disease COVID-19, requires therapeutic interventions that can be rapidly …

Dapsone and sulfones in dermatology: overview and update

YI Zhu, MJ Stiller - Journal of the American Academy of dermatology, 2001 - Elsevier
In their 60-year history, dapsone and the sulfones have been used as both antibacterial and
anti-inflammatory agents. Dapsone has been used successfully to treat a range of …

[KİTAP][B] Comprehensive dermatologic drug therapy

SE Wolverton, JJ Wu - 2019 - books.google.com
Designed with practical usability in mind, Comprehensive Dermatologic Drug Therapy, 4th
Edition, helps you safely and effectively treat the skin disorders you're likely to see in your …

Pyoderma gangrenosum–a review

U Wollina - Orphanet journal of rare diseases, 2007 - Springer
Pyoderma gangrenosum (PG) is a rare noninfectious neutrophilic dermatosis. Clinically it
starts with sterile pustules that rapidly progress and turn into painful ulcers of variable depth …

Cutaneous lupus erythematosus: update of therapeutic options: part II

A Kuhn, V Ruland, G Bonsmann - Journal of the American Academy of …, 2011 - Elsevier
In the first part of the review, topical agents and first-line systemic treatment options for
cutaneous lupus erythematosus were discussed whereas in the second part, recent …

[HTML][HTML] Pyrazine and phenazine heterocycles: platforms for total synthesis and drug discovery

RW Huigens, BR Brummel, S Tenneti, AT Garrison… - Molecules, 2022 - mdpi.com
Background: Open Access Editor's Choice Review Pyrazine and Phenazine Heterocycles:
Platforms for Total Synthesis and Drug Discovery by Robert W. Huigens III*, Beau R …

Safety and effectiveness of clofazimine for primary and refractory nontuberculous mycobacterial infection

SL Martiniano, BD Wagner, A Levin, JA Nick, SD Sagel… - Chest, 2017 - Elsevier
Background Clofazimine is an antimicrobial agent that has activity in vitro against
mycobacteria. Increasingly, it has been used for the treatment of nontuberculous …

[HTML][HTML] Clofazimine: a journey of a drug

J Xu, A Koval, VL Katanaev - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Among different strategies to develop novel therapies, drug repositioning (aka repurposing)
aims at identifying new uses of an already approved or investigational drug. This approach …