Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

Abstract Development of the retinal vasculature is based on highly coordinated signalling
between different cell types of the retina, integrating internal metabolic requirements with …

Excessive abnormal angiogenesis plays a pivotal role in tumor progression and is a
hallmark of solid tumors. This process is driven by an imbalance between pro-and anti …

Plaque microvascularization and increased endothelial permeability are key players in the
development of atherosclerosis, from the initial stages of plaque formation to the occurrence …

In contrast to the general belief, endothelial cell (EC) metabolism has recently been
identified as a driver rather than a bystander effect of angiogenesis in health and disease …

Glutamine synthetase, encoded by the gene GLUL, is an enzyme that converts glutamate
and ammonia to glutamine. It is expressed by endothelial cells, but surprisingly shows …

Preclinical and clinical antiangiogenic approaches, with multiple side effects such as
resistance, have not been proved to be very successful in treating tumor blood vessels …

Exercise-induced skeletal muscle angiogenesis is a well-known physiological adaptation
that occurs in humans in response to exercise training and can lead to endurance …

During vessel sprouting, endothelial cells (ECs) dynamically rearrange positions in the
sprout to compete for the tip position. We recently identified a key role for the glycolytic …

The endothelium is the orchestral conductor of blood vessel function. Pathological blood
vessel formation (a process termed pathological angiogenesis) or the inability of endothelial …