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COVID-19 drug discovery and treatment options
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused substantial morbidity and …
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused substantial morbidity and …
The drug repurposing for COVID-19 clinical trials provide very effective therapeutic combinations: lessons learned from major clinical studies
SARS-CoV-2 has spread across the globe in no time. In the beginning, people suffered due
to the absence of efficacious drugs required to treat severely ill patients. Nevertheless, still …
to the absence of efficacious drugs required to treat severely ill patients. Nevertheless, still …
Design, synthesis, and SAR studies of novel 4-methoxyphenyl pyrazole and pyrimidine derivatives as potential dual tyrosine kinase inhibitors targeting both EGFR …
Guided by the pharmacophoric features of both EGFR and VEGFR-2 antagonists, two novel
series of 4-methoxyphenyl pyrazole and pyrimidine derivatives [(4a-c) and (5a-c, 6, 7a-c, 8 …
series of 4-methoxyphenyl pyrazole and pyrimidine derivatives [(4a-c) and (5a-c, 6, 7a-c, 8 …
In silico and in vitro studies for benzimidazole anthelmintics repurposing as VEGFR-2 antagonists: novel mebendazole-loaded mixed micelles with enhanced …
Cancer is a leading cause of death worldwide and its incidence is unfortunately anticipated
to rise in the next years. On the other hand, vascular endothelial growth factor receptor 2 …
to rise in the next years. On the other hand, vascular endothelial growth factor receptor 2 …
In vitro and computational investigations of novel synthetic carboxamide-linked pyridopyrrolopyrimidines with potent activity as SARS-CoV-2-M Pro inhibitors
An essential target for COVID-19 is the main protease of SARS-CoV-2 (Mpro). With the
objective of targeting this receptor, a novel set of pyrido [1, 2-a] pyrrolo [2, 3-d] pyrimidines …
objective of targeting this receptor, a novel set of pyrido [1, 2-a] pyrrolo [2, 3-d] pyrimidines …
Bioactive Azadirachta indica and Melia azedarach leaves extracts with anti-SARS-CoV-2 and antibacterial activities
BA Hemdan, A Mostafa, MM Elbatanony, AM El-Feky… - Plos one, 2023 - journals.plos.org
The leaves of Azadirachta indica L. and Melia azedarach L., belonging to Meliaceae family,
have been shown to have medicinal benefits and are extensively employed in traditional folk …
have been shown to have medicinal benefits and are extensively employed in traditional folk …
[HTML][HTML] Protein structure-based in-silico approaches to drug discovery: Guide to COVID-19 therapeutics
With more than 5 million fatalities and close to 300 million reported cases, COVID-19 is the
first documented pandemic due to a coronavirus that continues to be a major health …
first documented pandemic due to a coronavirus that continues to be a major health …
[HTML][HTML] Naturally available flavonoid aglycones as potential antiviral drug candidates against SARS-CoV-2
Flavonoids are important secondary plant metabolites that have been studied for a long time
for their therapeutic potential in inflammatory diseases because of their cytokine-modulatory …
for their therapeutic potential in inflammatory diseases because of their cytokine-modulatory …
Phenylpyrazolone-1, 2, 3-triazole hybrids as potent antiviral agents with promising SARS-CoV-2 main protease inhibition potential
COVID-19 infection is now considered one of the leading causes of human death. As an
attempt towards the discovery of novel medications for the COVID-19 pandemic, nineteen …
attempt towards the discovery of novel medications for the COVID-19 pandemic, nineteen …
Newly synthesized series of oxoindole–oxadiazole conjugates as potential anti-SARS-CoV-2 agents: In silico and in vitro studies
In this study, a series of 1, 3, 4-oxadiazoles carrying the isatin moiety (IVa–g) as anti-SARS-
CoV-2 agents were designed and synthesized. Molecular docking of the compounds (IVa–g) …
CoV-2 agents were designed and synthesized. Molecular docking of the compounds (IVa–g) …