Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …

In all eukaryotes, morphogenesis of the microtubule cytoskeleton into a bipolar spindle is
required for the faithful transmission of the genome to the two daughter cells during division …

Cytoskeletal microtubules have been proposed to influence cell shape and mechanics
based on their ability to resist large-scale compressive forces exerted by the surrounding …

Spindle assembly required during mitosis depends on microtubule polymerization. We
demonstrate that the evolutionarily conserved low-complexity protein, BuGZ, undergoes …

A molecular motor is made of either a single macromolecule or a macromolecular complex.
Just like their macroscopic counterparts, molecular motors “transduce” input energy into …

Mitotic spindle morphogenesis is a series of highly coordinated movements that lead to
chromosome segregation and cytokinesis. We report that the intermediate filament protein …

The mitotic spindle accurately segregates genetic instructions by moving chromosomes to
spindle poles (anaphase A) and separating the poles (anaphase B) so that, in general, the …

Background The pole-to-pole distance of the metaphase spindle is reasonably constant in a
given cell type; in the case of vertebrate female oocytes, this steady-state length can be …

Asymmetric cell division requires the orientation of mitotic spindles along the cell-polarity
axis. In Drosophila neuroblasts, this involves the interaction of the proteins Inscuteable (Insc) …

The midzone is the domain of the mitotic spindle that maintains spindle bipolarity during
anaphase and generates forces required for spindle elongation (anaphase B). Although …