Improving the survival of patients with osteosarcoma has long proved challenging, although
the treatment of this disease is on the precipice of advancement. The increasing feasibility of …

Clinical outcomes and treatment modalities for osteosarcoma, the most common primary
cancer of bone, have changed very little over the past 30 years. The peak incidence of …

High-grade osteosarcomas are the most common primary malignant tumors of bone. With
complete surgical resection and multi-agent chemotherapy up to 70% of patients with high …

Accelerating cures for children with cancer remains an immediate challenge as a result of
extensive oncogenic heterogeneity between and within histologies, distinct molecular …

Osteosarcoma is the most common primary malignant bone tumor, predominantly occurring
in children and adolescents. Despite treated with surgery and neoadjuvant chemotherapy …

Rare hereditary disorders provide unequivocal evidence of the importance of genes in
human disease pathogenesis. Familial syndromes that predispose to osteosarcomagenesis …

TP53 is the most frequently mutated gene in human cancer. This gene shows not only loss‐
of‐function mutations but also recurrent missense mutations with gain‐of‐function activity …

Simple Summary Treatment of osteosarcoma, apart from chemotherapy modifications, has
not changed for approximately 30 years. Similarly, as in other tumors, mutations in the TP53 …

Osteosarcoma is the most common primary tumor of bone. Osteosarcomas are rare in
humans, but occur more commonly in dogs. A comparative approach to studying …

Osteosarcoma (OS) is the most common primary bone malignancy and is frequently lethal
via metastasis to the lung. While surgical techniques and adjuvant chemotherapies have …