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[HTML][HTML] The role of lysosomal cathepsins in neurodegeneration: Mechanistic insights, diagnostic potential and therapeutic approaches
Lysosomes are ubiquitous organelles with a fundamental role in maintaining cellular
homeostasis by mediating degradation and recycling processes. Cathepsins are the most …
homeostasis by mediating degradation and recycling processes. Cathepsins are the most …
A new kid in the folding funnel: Molecular chaperone activities of the BRICHOS domain
The BRICHOS protein superfamily is a diverse group of proteins associated with a wide
variety of human diseases, including respiratory distress, COVID‐19, dementia, and cancer …
variety of human diseases, including respiratory distress, COVID‐19, dementia, and cancer …
Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain
Protein misfolding can generate toxic intermediates, which underlies several devastating
diseases, such as Alzheimer's disease (AD). The surface of AD-associated amyloid-β …
diseases, such as Alzheimer's disease (AD). The surface of AD-associated amyloid-β …
Doing what spiders cannot—A road map to supreme artificial silk fibers
Fabricating artificial spider silk fibers in bulk scale has been a major goal in materials
science for centuries. Two main routes have emerged for making such fibers. One method …
science for centuries. Two main routes have emerged for making such fibers. One method …
Abilities of the BRICHOS domain to prevent neurotoxicity and fibril formation are dependent on a highly conserved Asp residue
Proteins can self-assemble into amyloid fibrils or amorphous aggregates and thereby cause
disease. Molecular chaperones can prevent both these types of protein aggregation, but to …
disease. Molecular chaperones can prevent both these types of protein aggregation, but to …
Short hydrophobic loop motifs in BRICHOS domains determine chaperone activity against amorphous protein aggregation but not against amyloid formation
ATP-independent molecular chaperones are important for maintaining cellular fitness but
the molecular determinants for preventing aggregation of partly unfolded protein substrates …
the molecular determinants for preventing aggregation of partly unfolded protein substrates …
[HTML][HTML] Bri2 BRICHOS chaperone rescues impaired fast-spiking interneuron behavior and neuronal network dynamics in an AD mouse model in vitro
Synchronized and properly balanced electrical activity of neurons is the basis for the brain's
ability to process information, to learn, and to remember. In Alzheimer's disease (AD), which …
ability to process information, to learn, and to remember. In Alzheimer's disease (AD), which …
[HTML][HTML] Identification of cytoskeletal proteins as binding partners of Bri2 BRICHOS domain
Proteins must fold into three-dimensional structures to execute their biological functions.
Therefore, maintenance of protein homeostasis, proteostasis, including prevention of protein …
Therefore, maintenance of protein homeostasis, proteostasis, including prevention of protein …
Molecular basis for different substrate‐binding sites and chaperone functions of the BRICHOS domain
Proteins can misfold into fibrillar or amorphous aggregates and molecular chaperones act
as crucial guardians against these undesirable processes. The BRICHOS chaperone …
as crucial guardians against these undesirable processes. The BRICHOS chaperone …
[HTML][HTML] Exploring the role of British dementia protein-2 (Bri2) and its BRICHOS domain in neurodegenerative disorders
Protein functionality hinges on precise three-dimensional structures, while molecular
chaperones orchestrate folding, proteome maintenance, and proteostasis. Recent attention …
chaperones orchestrate folding, proteome maintenance, and proteostasis. Recent attention …