Although the entire coronary tree is exposed to the atherogenic effect of the systemic risk
factors, atherosclerotic lesions form at specific arterial regions, where low and oscillatory …

Although the pathobiology of atherosclerosis is a complex multifactorial process, blood flow-
induced shear stress has emerged as an essential feature of atherogenesis. This fluid drag …

Expert recommendations on the assessment of wall shear stress in human coronary arteries:
existing methodologies, technical considerations, and clinical applications | European Heart …

This paper reviews the methods, benefits and challenges associated with the adoption and
translation of computational fluid dynamics (CFD) modelling within cardiovascular medicine …

The heterogeneity of plaque formation, the vascular remodelling response to plaque
formation, and the consequent phenotype of plaque instability attest to the extraordinarily …

Atherosclerosis is the main cause of morbidity and mortality in the Western world.
Inflammation and blood flow alterations are new markers emerging as possible …

Restenosis and thrombosis are potentially fatal complications of coronary stenting with a
recognized multifactorial etiology. The effect of documented risk factors, however, cannot …

Background—Native atherosclerosis and in-stent restenosis are focal and evolve
independently. The endothelium controls local arterial responses by transduction of shear …

Background—Low endothelial shear stress (ESS) promotes the development of
atherosclerosis; however, its role in the progression of atherosclerotic plaques and evolution …

Local hemodynamics are an important factor in atherosclerosis, from the development of
early lesions, to the assessment of stroke risk, to determining the ultimate fate of a mature …