As the most dangerous tumors, brain tumors are usually treated with surgical removal,
radiation therapy, and chemotherapy. However, due to the aggressive growth of gliomas …

Traditional anti-cancer treatments are inefficient against glioblastoma, which remains one of
the deadliest and most aggressive cancers. Nano-drugs could help to improve this situation …

Abstract Background Histone deacetylases (HDACs) are one of the essential epigenetic
targets in cancer treatment. These enzymes play key roles in post-translation modification …

Even though the last decade has seen a surge in the identification of molecular targets and
targeted therapies in pediatric brain tumors, the blood brain barrier (BBB) remains a …

Diffuse midline gliomas harboring the H3 K27M mutation—including the previously named
diffuse intrinsic pontine glioma (DIPG)—are lethal high-grade pediatric brain tumors that are …

Inhibiting epigenetic modulators can transcriptionally reactivate transposable elements
(TEs). These TE transcripts often generate unique peptides that can serve as immunogenic …

Background The objective of this study was to determine the safety, tolerability, and
distribution of MTX110 (aqueous panobinostat) delivered by convection-enhanced delivery …

The prevalence of neurological/neurodegenerative diseases, such as Alzheimer's disease is
known to be increasing due to an aging population and is anticipated to further grow in the …

OBJECTIVE The pan–histone deacetylase inhibitor panobinostat has preclinical efficacy
against diffuse intrinsic pontine glioma (DIPG), and the oral formulation has entered a Phase …

Even though some progress in diagnosis and treatment has been made over the years,
there is still no definitive treatment available for Glioblastoma multiforme (GBM). Convection …