Regulation of microtubule dynamics, mechanics and function through the growing tip
Microtubule dynamics and their control are essential for the normal function and division of
all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic …
all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic …
Plant-derived anticancer compounds as new perspectives in drug discovery and alternative therapy
CA Dehelean, I Marcovici, C Soica, M Mioc… - Molecules, 2021 - mdpi.com
Despite the recent advances in the field of chemically synthetized pharmaceutical agents,
nature remains the main supplier of bioactive molecules. The research of natural products is …
nature remains the main supplier of bioactive molecules. The research of natural products is …
Structure of dynein–dynactin on microtubules shows tandem adaptor binding
Cytoplasmic dynein is a microtubule motor that is activated by its cofactor dynactin and a
coiled-coil cargo adaptor,–. Up to two dynein dimers can be recruited per dynactin, and …
coiled-coil cargo adaptor,–. Up to two dynein dimers can be recruited per dynactin, and …
Cryo-EM in drug discovery: achievements, limitations and prospects
Cryo-electron microscopy (cryo-EM) of non-crystalline single particles is a biophysical
technique that can be used to determine the structure of biological macromolecules and …
technique that can be used to determine the structure of biological macromolecules and …
The tubulin code in microtubule dynamics and information encoding
Microtubules are non-covalent mesoscale polymers central to the eukaryotic cytoskeleton.
Microtubule structure, dynamics, and mechanics are modulated by a cell's choice of tubulin …
Microtubule structure, dynamics, and mechanics are modulated by a cell's choice of tubulin …
Microtubule-targeting agents: strategies to hijack the cytoskeleton
Microtubule-targeting agents (MTAs) such as paclitaxel and the vinca alkaloids are among
the most important medical weapons available to combat cancer. MTAs interfere with …
the most important medical weapons available to combat cancer. MTAs interfere with …
Near-atomic model of microtubule-tau interactions
Tau is a developmentally regulated axonal protein that stabilizes and bundles microtubules
(MTs). Its hyperphosphorylation is thought to cause detachment from MTs and subsequent …
(MTs). Its hyperphosphorylation is thought to cause detachment from MTs and subsequent …
Triple negative breast cancer: approved treatment options and their mechanisms of action
Purpose Breast cancer, the most prevalent cancer worldwide, consists of 4 main subtypes,
namely, Luminal A, Luminal B, HER2-positive, and Triple-negative breast cancer (TNBC) …
namely, Luminal A, Luminal B, HER2-positive, and Triple-negative breast cancer (TNBC) …
Structural and functional insight into regulation of kinesin-1 by microtubule-associated protein MAP7
Microtubule (MT)–associated protein 7 (MAP7) is a required cofactor for kinesin-1–driven
transport of intracellular cargoes. Using cryo–electron microscopy and single–molecule …
transport of intracellular cargoes. Using cryo–electron microscopy and single–molecule …
Microtubule nucleation: beyond the template
Microtubules are cytoskeletal filaments central to a wide range of essential cellular functions
in eukaryotic cells. Consequently, cells need to exert tight control over when, where and how …
in eukaryotic cells. Consequently, cells need to exert tight control over when, where and how …