Osteoarthritis (OA) is a major cause of disability and socioeconomic loss worldwide.
However, the current pharmacological approaches used to treat OA are largely palliative …

Purpose To provide an updated review of the literature on the use of orthobiologics as a
potential treatment option to alleviate symptoms associated with osteoarthritis (OA), slow the …

Objectives The aim of this study was to identify biomarkers for radiographic OA severity and
progression acting within the inflammation and metabolic pathways. Methods For 3517 …

Osteoarthritis (OA) is a slow-progressing joint disease, leading to the degradation and
remodeling of the cartilage extracellular matrix (ECM). The usually quiescent chondrocytes …

Objective To provide an insightful summary of studies on biochemical markers for
osteoarthritis (OA). Design Two investigators systematically searched the electronic PubMed …

Osteoarthritis (OA) affects more than 500 million people worldwide and is among the five
diseases in Germany causing the highest suffering of the patients and cost for the society …

Abstract Thrombospondin-4 (TSP-4) belongs to the extracellular matrix glycoprotein family of
thrombospondins (TSPs). The multidomain, pentameric structure of TSP-4 allows its …

Osteoarthritis (OA) ranks as the prevailing type of arthritis on a global scale, for which no
effective treatments are currently available. Arterial hypertension is a common comorbidity in …

Osteoarthritis (OA) is a leading cause of disability and source of societal cost in older adults.
It is a whole-joint disease in which all components of the joint are affected involving …

Objective Due to the small size of the murine knee joint, extracting the chondrocyte
transcriptome from articular cartilage (AC) is a major technical challenge. In this study, we …