Fibrinogen conversion into insoluble fibrin and the formation of a stable clot is the final step
of the coagulation cascade. Fibrin clot porosity and its susceptibility to plasmin-mediated …

Background and Purpose: Population-wide reductions in cardiovascular disease incidence
and mortality have not been shared equally by African Americans. The burden of …

In Japan, a super-aged society, deaths from atherosclerotic cardiovascular disease
(ASCVD), especially cardiac diseases including coronary artery disease (CAD) such as …

Every 5 years, the JAS publishes guidelines for the treatment of dyslipidemia and
atherosclerosis. To date, this society has released four such guidelines. Since 2007, the JAS …

Importance Systematic reviews and meta-analyses of individual participant data (IPD) aim to
collect, check, and reanalyze individual-level data from all studies addressing a particular …

Atherosclerotic cardiovascular diseases (ASCVD), including coronary artery disease,
cerebrovascular disease, and peripheral arterial disease, represent a significant cause of …

Fibrinogen is an abundant protein synthesized in the liver, present in human blood plasma
at concentrations ranging from 1.5-4 g/L in healthy individuals with a normal half-life of 3-5 …

Aims Because low-grade inflammation may play a role in the pathogenesis of coronary heart
disease (CHD), and pro-inflammatory cytokines govern inflammatory cascades, this study …

Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. The
primary prevention of CVD is dependent upon the ability to identify high-risk individuals long …

Background There is debate about the value of assessing levels of C-reactive protein (CRP)
and other biomarkers of inflammation for the prediction of first cardiovascular events …