The selection of appropriate outcomes is crucial when designing clinical trials in order to
compare the effects of different interventions directly. For the findings to influence policy and …

Advances in the treatment of childhood cancers have resulted in part from the development
of national and international collaborative initiatives that have defined biologic determinants …

After identification of an important research question and selection of an appropriate study
design, waste can arise from the regulation, governance, and management of biomedical …

Objective There is a widely held assumption that engagement by clinicians and healthcare
organisations in research improves healthcare performance at various levels, but little direct …

Objective In 2001, the National Institute for Health Research Cancer Research Network
(NCRN) was established, leading to a rapid increase in clinical research activity across the …

Objective The aim of the present study was to determine whether there is an association
between having research culture in a health service and better organisational performance …

Rationale, aims and objectives Clinical research activity in hospitals is associated with
reduced mortality and improved overall care quality. In England, the latter is a compound …

Participation in randomised clinical trials (RCTs) entails taking part in the discovery of effects
of health care interventions. The question of whether participants' outcomes are different to …

Objectives Evidence supporting the notion that clinical research activity in itself is of benefit
to organisations as a whole is inconclusive. In the recent past, a positive association …

Background A significant barrier to conducting clinical trials is their high cost, which is driven
primarily by the time and resources required to activate trials and reach accrual targets. The …