Thiazole-based thiosemicarbazones: Synthesis, cytotoxicity evaluation and molecular docking study

SM Gomha, HA Abdelhady, DZH Hassain… - Drug Design …, 2021 - Taylor & Francis
Introduction Hybrid drug design has developed as a prime method for the development of
novel anticancer therapies that can theoretically solve much of the pharmacokinetic …

[HTML][HTML] Synthesis of novel aminothiazole derivatives as promising antiviral, antioxidant and antibacterial candidates

R Minickaitė, B Grybaitė, R Vaickelionienė… - International Journal of …, 2022 - mdpi.com
It is well-known that thiazole derivatives are usually found in lead structures, which
demonstrate a wide range of pharmacological effects. The aim of this research was to …

Microwave-Assisted One-Pot Telescoped Synthesis of 2-Amino-1,3-thiazoles, Selenazoles, Imidazo[1,2-a]pyridines, and Other Heterocycles from Alcohols

P Macías-Benítez, A Sierra-Padilla… - The Journal of …, 2024 - ACS Publications
Primary and secondary alcohols have been converted into 2-amino-1, 3-thiazoles under
microwave irradiation, employing trichloroisocyanuric acid (TCCA) as a dual oxidant and …

Three-component p-TSA catalyzed synthesis of hydrazinyl thiazole derivatives

SL Kumar, SJ Chundattu, S Govindaraju… - Materials Today …, 2024 - Elsevier
A direct single-pot three-component procedure for synthesizing bio-active hydrazinyl
thiazole derivatives has been demonstrated. The reaction involves substituted 2 …

Thiocyanatoarylation of Methyl Vinyl Ketone under Meerwein Conditions for the Synthesis of 2-Aminothiazole-Based Heterocyclic Systems

YV Ostapiuk, OV Barabash, MY Ostapiuk… - Organic …, 2022 - ACS Publications
4-Aryl-3-thiocyanatobutan-2-ones were prepared by Meerwein reactions from methyl vinyl
ketone and aryldiazonium salts under copper (II) catalysis in 35–75% yields. α-Thiocyanato …

Inhibiting brushite crystal growth: molecular docking exploration of Enhydra fluctuans phytoconstituents and their interaction with human serum albumin

A Nandi, B Chattaraj, A Das, R Prasad… - Journal of Biomolecular …, 2024 - Taylor & Francis
In our preliminary in vitro studies, the Enhydra fluctuans extract demonstrated inhibition of
calcium phosphate (brushite) crystals. Human serum albumin (HSA) is known to act as a …

[HTML][HTML] One-pot synthesis of 4-aryl-2-aminothiazoles from styrenes and thioureas promoted by tribromoisocyanuric acid

VSC de Andrade, MCS de Mattos - Tetrahedron Letters, 2020 - Elsevier
A simple and efficient one-pot protocol has been developed for the conversion of styrenes
into 4-aryl-2-aminothiazoles using readily available starting materials. Tribromoisocyanuric …

Synthesis, Reaction, and Biological Activity of Thiazoles

AM Alateeq, YS Al-Faiyz, OD McNair… - Current Organic …, 2024 - benthamdirect.com
The current review aimed to provide an understanding of the preparation, reactions, and
biological action of thiazoles. The purpose of this review was to focus on the progress made …

Design, synthesis, cytotoxic activity and molecular docking studies of naphthyl pyrazolyl thiazole derivatives as anticancer agents

HA Abd El Salam, U Fathy, EM Zayed… - …, 2023 - Wiley Online Library
Novel series of heterocycliccompounds pairing hybrids pyrazole, naphthalene and
pyrazoline/thiazoldinemoieties were synthesized. The starting compounds pyrazolyl …

One-pot syntheses of substituted 2-aminothiazoles and 2-aminoselenazoles via Meerwein arylation of alkyl vinyl ketones

YV Ostapiuk, MY Ostapiuk, OV Barabash, M Kravets… - …, 2022 - thieme-connect.com
Both one-pot and two-step procedures for the synthesis of substituted 2-aminothiazoles and
2-aminoselenazoles are described. Anilines are first converted into arenediazonium …