Carnosine is a dipeptide synthesized in the body from β-alanine and L-histidine. It is found
in high concentrations in the brain, muscle, and gastrointestinal tissues of humans and is …

There is growing evidence that supplementation with carnosine, or its rate-limiting precursor
β-alanine, can ameliorate aspects of metabolic dysregulation that occur in diabetes and its …

Spexin is a novel peptide implicated in obesity and energy homeostasis. The objective of the
current study was to evaluate the effect of spexin on blood pressure, insulin resistance, and …

Carbonyl stress is a condition characterized by an increase in the steady-state levels of
reactive carbonyl species (RCS) that leads to accumulation of their irreversible covalent …

Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and
mortality in patients with prediabetes and type 2 diabetes mellitus (T2DM). Carnosine has …

Background/Objectives: In vitro studies suggest that carnosine reduces inflammation by
upregulating anti-inflammatory mediators and downregulating pro-inflammatory cytokines …

Background Early diagnosis and treatment significantly improve the prognosis of coronary
heart disease (CHD), but no convenient screening tools are available. This study aims to …

Many women have sought alternative therapies to address menopause. Recently, a multi-
ingredient supplement (MIS) containing L-histidine, L-carnosine, L-serine, and L-cysteine …

Human serum carnosinase is an enzyme that operates the preferential hydrolysis of
dipeptides with a C-terminus histidine. Only higher primates excrete such an enzyme in …

Reactive carbonyl species (RCS) may originate from the oxidation of unsaturated fatty acids
and sugar in conditions of pathology. They are known to have high reactivity towards DNA …