Physics of adherent cells
One of the most unique physical features of cell adhesion to external surfaces is the active
generation of mechanical force at the cell-material interface. This includes pulling forces …
generation of mechanical force at the cell-material interface. This includes pulling forces …
Mechanisms of myosin II force generation: insights from novel experimental techniques and approaches
DE Rassier, A Månsson - Physiological Reviews, 2025 - journals.physiology.org
Myosin II is a molecular motor that converts chemical energy derived from ATP hydrolysis
into mechanical work. Myosin II isoforms are responsible for muscle contraction and a range …
into mechanical work. Myosin II isoforms are responsible for muscle contraction and a range …
Stochastic mechano-chemical kinetics of molecular motors: a multidisciplinary enterprise from a physicist's perspective
D Chowdhury - Physics Reports, 2013 - Elsevier
A molecular motor is made of either a single macromolecule or a macromolecular complex.
Just like their macroscopic counterparts, molecular motors “transduce” input energy into …
Just like their macroscopic counterparts, molecular motors “transduce” input energy into …
MEDYAN: mechanochemical simulations of contraction and polarity alignment in actomyosin networks
Active matter systems, and in particular the cell cytoskeleton, exhibit complex
mechanochemical dynamics that are still not well understood. While prior computational …
mechanochemical dynamics that are still not well understood. While prior computational …
Physics of muscle contraction
In this paper we report, clarify and broaden various recent efforts to complement the
chemistry-centered models of force generation in (skeletal) muscles by mechanics-centered …
chemistry-centered models of force generation in (skeletal) muscles by mechanics-centered …
Coordination and collective properties of molecular motors: theory
Many cellular processes require molecular motors to produce motion and forces. Single
molecule experiments have led to a precise description of how a motor works. Under most …
molecule experiments have led to a precise description of how a motor works. Under most …
Distinct roles of nonmuscle myosin II isoforms for establishing tension and elasticity during cell morphodynamics
Abstract Nonmuscle myosin II (NM II) is an integral part of essential cellular processes,
including adhesion and migration. Mammalian cells express up to three isoforms termed NM …
including adhesion and migration. Mammalian cells express up to three isoforms termed NM …
Three-dimensional stochastic model of actin–myosin binding in the sarcomere lattice
The effect of molecule tethering in three-dimensional (3-D) space on bimolecular binding
kinetics is rarely addressed and only occasionally incorporated into models of cell motility …
kinetics is rarely addressed and only occasionally incorporated into models of cell motility …
Spontaneous oscillations of a minimal actomyosin system under elastic loading
Spontaneous mechanical oscillations occur in various types of biological systems where
groups of motor molecules are elastically coupled to their environment. By using an optical …
groups of motor molecules are elastically coupled to their environment. By using an optical …
Stochastic force generation by small ensembles of myosin II motors
T Erdmann, US Schwarz - Physical review letters, 2012 - APS
Forces in the actin cytoskeleton are generated by small groups of nonprocessive myosin II
motors for which stochastic effects are highly relevant. Using a cross-bridge model with the …
motors for which stochastic effects are highly relevant. Using a cross-bridge model with the …