Beyond potency, a good developability profile is a key attribute of a biological drug.
Selecting and screening for such attributes early in the drug development process can save …

Recent progress in epitope prediction has shown promising results in the development of
vaccines and therapeutics against various diseases. However, the overall accuracy and …

Therapeutic antibodies make up a rapidly growing segment of the biologics market.
However, rational design of antibodies is hindered by reliance on experimental methods for …

Protein folding is a fascinating, not fully understood phenomenon in biology. Molecular
dynamics (MD) simulations are an invaluable tool to study conformational changes in …

Advances in structural biology and the exponential increase in the amount of high-quality
experimental structural data available in the Protein Data Bank has motivated numerous …

This perspective sheds light on the transformative impact of recent computational
advancements in the field of protein therapeutics, with a particular focus on the design and …

In the last decades, antibodies have emerged as one of the most important and successful
classes of biopharmaceuticals. The highest variability and diversity of an antibody is …

Predicting the structure of antibody-antigen complexes has tremendous value in biomedical
research but unfortunately suffers from a poor performance in real-life applications …

Abstract BCRs (Abs) and TCRs (or adaptive immune receptors [AIRs]) are the means by
which the adaptive immune system recognizes foreign and self-antigens, playing an integral …

During the affinity maturation process the immune system produces antibodies with higher
specificity and activity through various rounds of somatic hypermutations in response to an …