Gut microbiota and its metabolites in depression: from pathogenesis to treatment

L Liu, H Wang, X Chen, Y Zhang, H Zhang, P **e - EBioMedicine, 2023 - thelancet.com
Major depressive disorder is one of the most disabling mental disorders worldwide.
Increasing preclinical and clinical studies have highlighted that compositional and functional …

Gut liver brain axis in diseases: the implications for therapeutic interventions

M Yan, S Man, B Sun, L Ma, L Guo, L Huang… - Signal transduction and …, 2023 - nature.com
Gut-liver-brain axis is a three-way highway of information interaction system among the
gastrointestinal tract, liver, and nervous systems. In the past few decades, breakthrough …

Perturbations in gut microbiota composition in psychiatric disorders: a review and meta-analysis

VL Nikolova, MRB Smith, LJ Hall, AJ Cleare… - JAMA …, 2021 - jamanetwork.com
Importance Evidence of gut microbiota perturbations has accumulated for multiple
psychiatric disorders, with microbiota signatures proposed as potential biomarkers …

[HTML][HTML] The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders

K Socała, U Doboszewska, A Szopa, A Serefko… - Pharmacological …, 2021 - Elsevier
Emerging evidence indicates that the gut microbiota play a crucial role in the bidirectional
communication between the gut and the brain suggesting that the gut microbes may shape …

[HTML][HTML] Brain–gut–microbiota axis in depression: A historical overview and future directions

L Chang, Y Wei, K Hashimoto - Brain Research Bulletin, 2022 - Elsevier
Depression is the most common mental disorder and a leading cause of disability
worldwide. Despite abundant research, the precise mechanisms underlying the …

Gut microbiome dysbiosis across early Parkinson's disease, REM sleep behavior disorder and their first-degree relatives

B Huang, SWH Chau, Y Liu, JWY Chan, J Wang… - Nature …, 2023 - nature.com
The microbiota-gut-brain axis has been suggested to play an important role in Parkinson's
disease (PD). Here we performed a cross-sectional study to profile gut microbiota across …

Gut microbiome-wide association study of depressive symptoms

D Radjabzadeh, JA Bosch, AG Uitterlinden… - Nature …, 2022 - nature.com
Depression is one of the most poorly understood diseases due to its elusive pathogenesis.
There is an urgency to identify molecular and biological mechanisms underlying depression …

Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity

M Zhao, Z Ren, A Zhao, Y Tang, J Kuang, M Li, T Chen… - Cell Metabolism, 2024 - cell.com
The gut-brain axis is implicated in depression development, yet its underlying mechanism
remains unclear. We observed depleted gut bacterial species, including Bifidobacterium …

Multi-omics analyses of serum metabolome, gut microbiome and brain function reveal dysregulated microbiota-gut-brain axis in bipolar depression

Z Li, J Lai, P Zhang, J Ding, J Jiang, C Liu… - Molecular …, 2022 - nature.com
The intricate processes of microbiota-gut-brain communication in modulating human
cognition and emotion, especially in the context of mood disorders, have remained elusive …