In situ, cells are highly sensitive to geometrical and mechanical constraints from their
microenvironment. These parameters are, however, uncontrolled under classic culture …

More than a century ago, it was proposed that mechanical forces could drive tissue
formation. However, only recently with the advent of enabling biophysical and molecular …

Commitment of stem cells to different lineages is regulated by many cues in the local tissue
microenvironment. Here we demonstrate that cell shape regulates commitment of human …

The cellular microenvironment plays an integral role in improving the function of
microengineered tissues. Control of the microarchitecture in engineered tissues can be …

Organized cellular alignment is critical to controlling tissue microarchitecture and biological
function. Although a multitude of techniques have been described to control cellular …

Control of cell proliferation is a fundamental aspect of tissue physiology central to
morphogenesis, wound healing, and cancer. Although many of the molecular genetic factors …

▪ Abstract Mechanical forces play an important role in the organization, growth, maturation,
and function of living tissues. At the cellular level, many of the biological responses to …

Volumetric muscle loss (VML) is associated with a severe loss of muscle tissue that
overwhelms the regenerative potential of skeletal muscles. Tissue engineering has shown …

Recent progress in the biology of cell adhesion is enabling cell culture models to better
reproduce in vivo functions. Cues from adhesion to extracellular matrix and neighboring …

The integration of microfluidics with biomedical research is confronted with considerable
limitations due to its body materials. With high content of water, hydrogels own superior …