Cellular and whole organism iron homeostasis must be balanced to supply enough iron for
metabolism and to avoid excessive, toxic levels. To perform iron uptake from the …

Iron has emerged as a significant cause of neurotoxicity in several neurodegenerative
conditions, including Alzheimer's disease (AD), Parkinson's disease (PD), sporadic …

Yeast cells contain a family of three monothiol glutaredoxins: Grx3, 4, and 5. Absence of
Grx5 leads to constitutive oxidative damage, exacerbating that caused by external oxidants …

Abstract Iron–sulfur (Fe–S) clusters are ancient, ubiquitous cofactors composed of iron and
inorganic sulfur. The combination of the chemical reactivity of iron and sulfur, together with …

To acquire iron, all species have to overcome the problems of iron insolubility and toxicity. In
response to low iron availability in the environment, most fungi excrete ferric iron-specific …

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Iron is an essential element for all eukaryotes. The facile ability of iron to gain and lose
electrons permits its participation in a wide variety of oxidation-reduction reactions. Further …

Iron, copper, and zinc are all essential nutrients. The electron transfer properties of iron and
copper are fundamental to processes such as respiration and photosynthesis. Zinc forms the …

▪ Abstract Transition metals such as iron, copper, manganese, and zinc are essential
nutrients. The yeast Saccharomyces cerevisiae is an ideal organism for deciphering the …

The transcription of iron uptake and storage genes in Saccharomyces cerevisiae is primarily
regulated by the transcription factor Aft1. Nucleocytoplasmic shuttling of Aft1 is dependent …