Target protection as a key antibiotic resistance mechanism
Antibiotic resistance is mediated through several distinct mechanisms, most of which are
relatively well understood and the clinical importance of which has long been recognized …
relatively well understood and the clinical importance of which has long been recognized …
ATP‐binding cassette (ABC) transporters in cancer: A review of recent updates
The ATP‐binding cassette (ABC) transporter superfamily is one of the largest membrane
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …
Bacterial ribosome collision sensing by a MutS DNA repair ATPase paralogue
Ribosome stalling during translation is detrimental to cellular fitness, but how this is sensed
and elicits recycling of ribosomal subunits and quality control of associated mRNA and …
and elicits recycling of ribosomal subunits and quality control of associated mRNA and …
RAPP-containing arrest peptides induce translational stalling by short circuiting the ribosomal peptidyltransferase activity
Arrest peptides containing RAPP (ArgAlaProPro) motifs have been discovered in both Gram-
positive and Gram-negative bacteria, where they are thought to regulate expression of …
positive and Gram-negative bacteria, where they are thought to regulate expression of …
Resolution of ribosomal stalling by EF-P and ABCF ATPases YfmR and YkpA/YbiT
H Takada, K Fujiwara, GC Atkinson… - Nucleic Acids …, 2024 - academic.oup.com
Efficiency of protein synthesis on the ribosome is strongly affected by the amino acid
composition of the assembled amino acid chain. Challenging sequences include proline …
composition of the assembled amino acid chain. Challenging sequences include proline …
Global regulation via modulation of ribosome pausing by the ABC-F protein EttA
F Ousalem, S Ngo, T Oïffer, A Omairi-Nasser… - Nature …, 2024 - nature.com
Having multiple rounds of translation of the same mRNA creates dynamic complexities
along with opportunities for regulation related to ribosome pausing and stalling at specific …
along with opportunities for regulation related to ribosome pausing and stalling at specific …
Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens
Target protection proteins confer resistance to the host organism by directly binding to the
antibiotic target. One class of such proteins are the antibiotic resistance (ARE) ATP-binding …
antibiotic target. One class of such proteins are the antibiotic resistance (ARE) ATP-binding …
Genome-encoded ABCF factors implicated in intrinsic antibiotic resistance in Gram-positive bacteria: VmlR2, Ard1 and CplR
N Obana, H Takada, C Crowe-McAuliffe… - Nucleic Acids …, 2023 - academic.oup.com
Genome-encoded antibiotic resistance (ARE) ATP-binding cassette (ABC) proteins of the F
subfamily (ARE-ABCFs) mediate intrinsic resistance in diverse Gram-positive bacteria. The …
subfamily (ARE-ABCFs) mediate intrinsic resistance in diverse Gram-positive bacteria. The …
[HTML][HTML] ABCF ATPases involved in protein synthesis, ribosome assembly and antibiotic resistance: structural and functional diversification across the tree of life
Within the larger ABC superfamily of ATPases, ABCF family members eEF3 in
Saccharomyces cerevisiae and EttA in Escherichia coli have been found to function as …
Saccharomyces cerevisiae and EttA in Escherichia coli have been found to function as …
Comprehensive classification of ABC ATPases and their functional radiation in nucleoprotein dynamics and biological conflict systems
ABC ATPases form one of the largest clades of P-loop NTPase fold enzymes that catalyze
ATP-hydrolysis and utilize its free energy for a staggering range of functions from transport to …
ATP-hydrolysis and utilize its free energy for a staggering range of functions from transport to …